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dc.contributor.authorKimanthi, Jane M
dc.date.accessioned2017-01-06T04:31:09Z
dc.date.available2017-01-06T04:31:09Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/11295/99315
dc.description.abstractBackground: World Health Organization (WHO) defines adolescents as those aged 10–19 years. They represent 25% of the population in sub-Saharan Africa. Eighty-two percent of the estimated 2.1 million adolescents aged 10–19 years living with human immunodeficiency virus (HIV) in 2012 were in sub-Saharan Africa. Adherence to antiretroviral therapy (ART) is vital to HIV-infected adolescents for survival and quality of life. However, this age group faces many challenges to remain adherent. According to the Kenya National surveillance of acquired HIV drug resistance in 2013; only 67% of adolescents had viral suppression which reflects poor adherence. It is important to define adherence rates in different groups of adolescents and in the proposed study we explore adherence in those residing in rural areas. Objectives: The primary objective was to determine the level of optimal ART adherence among HIV infected adolescents on ART at the Kangundo District Hospital (KDH). The secondary objective was to describe the factors associated with adherence in the same population of adolescents. Methods: This was a retrospective study with a cross-sectional qualitative component. HIV infected adolescents aged 10 to 19 years who had been on ART and in care at KDH for at least six months were eligible. Disclosure status was determined from the caregiver and, adolescents who fulfilled the inclusion criteria were enrolled in to the study after informed written consent from caregiver and assent from the adolescent. Recent ART adherence was determined by 3, 7 and 30 days recall. Long term adherence was determined as follows: adherence to pharmacy refill with data abstracted from pharmacy database, and adherence to clinic appointments with data abstracted from hospital records for six months prior to the interview date. Factors associated with adherence to ART were sought including socio-demographic factors, clinical factors, drug related and health system related factors. Focus group discussions were held with HIV infected adolescents in care and who were aware of their HIV status to determine to a greater depth the factors impacting adherence Results: A total of 98 adolescents aged between 10 to 19 years were enrolled into the study with a median (interquartile range (IQR)) age of 14.0 (13.-16.) years. Majority (76.2%) were in their teenage years (13-19 years) and none of the respondents was married. Most (78.6%) were in, or had completed primary school while a few (17.3%) were in secondary school or had already completed secondary school education. Most of the participants (91.8%) were on first line ARV regimen with a median (IQR) duration on ART 6.3 (4.4-8.1) years. At the time of initiation of ART, 11.2%, 35.7% and 53.1% of the study participants were at Stage one, two and three/four of HIV/AIDS respectively as described in the WHO guidelines. Majority 65.3% of the participants had disclosure of their HIV status while the rest (34.7%) had not. The short term 3, 7 and 30 days optimal adherence, measured by self-report was poor with 76%, 55% and 69% being adherent respectively. Similarly the long term adherence over preceding 6 months as determined from hospital records was poor with only 66.3% being adherent to clinician’s appointment and 64.3% optimally adhering to drug refill appointments. From the univariate analysis several factor were shown to influence adherence negatively including: being in boarding school (OR 8.47, 95% CI 2.37-30.26, P=0.001), feeling tired of taking drugs daily (OR 0.13, 95% CI 0.05-0.37, P <0.001), reporting that dosing at specific times interfered with other daily activities (OR 0.27, 95% CI 0.10-0.71, P=0.006), non-disclosure of HIV status especially for adolescents aged >14 years (OR 8.5, 95% CI 1.57-46.08, P 0.009) and inconvenient appointment dates (OR 3.17, 95% CI 1,25-8.03, P 0.03). Clinicians’ behavior perceived as good/excellent (OR 4.79, 95% CI 1.28-17.91, P 0.032), similarly pharmacists’ behavior (OR 5.42, 95% CI 1.25-23.39, P 0.022) and adequate health education on HIV infection (OR 4.44, 95% CI 1.31-15.01, P 0.021) were associated with better adherence. Multivariable analysis revealed that adolescents who were in day school were more likely to be adherent compared to those who were in boarding school (adjusted odds ratio (aOR) 7.99, 95% CI 2.85 – 22.41, p<0.001). Appointments fitting with daily activities was associated with about four-fold increment in the likelihood of adherence to ART (aOR (95% CI) 4.22 (1.51-11.83), p=0.006). FGDs with adolescents’ revealed that good social support, disclosure about HIV status to the adolescents, to other family members and at least one person in school were perceived to improve adherence. Health providers’ behavior and attitude towards adolescents were also perceived to influence adherence with most adolescents reporting missed doses due to disappointments and dissatisfaction with the services provided at the clinic. Conclusion: We concluded that adherence to ART among this cohort of adolescents in a rural set up was poor as shown by the self- report, clinicians’ appointments and pharmacy refill appointments’. Poor adherence was significantly associated with age above 15 years, non-disclosure of HIV status, being in boarding school, feeling tired of taking drugs daily and dosing times interfering with other daily activities. Similarly, hostile health providers attitude, inadequate time spend by clinician addressing the adolescents needs, long waiting times, lack of privacy at the hospital and inconvenient timings of appointments were perceived as barriers to adherence. Stigmatization arising from the location of the CCC shows a need to re-design the service to protect confidentiality of adolescents living with HIV. Recommendations: Our findings suggest need for strengthening of interventions to assist adolescents’ in adhering to their medication including: Early disclosure, continuous psychosocial support, involvement of family and school “buddy” in adolescent care especially those in boarding schools. There is need to tailor the health services to be adolescent friendly at the level health provider, timing of appointments and privacy.en_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.titleAdherence to antiretroviral therapy among HIV infected adolescents at Kangundo District Hospital.en_US
dc.typeThesisen_US
dc.description.departmenta Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine, Moi University, Eldoret, Kenya


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