Three chalconoids and a pterocarpene from the roots of tephrosia aequilata.
Date
2017Author
Atilaw, Y
Duffy, S
Heydenreich, M
Muiva-Mutisya, L
Avery, VM
Erdélyi, M
Yenesew, A
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
In our search for new antiplasmodial agents, the CH₂Cl₂/CH₃OH (1:1) extract of the roots of Tephrosia aequilata was investigated, and observed to cause 100% mortality of the chloroquine-sensitive (3D7) strain of Plasmodium falciparum at a 10 mg/mL concentration. From this extract three new chalconoids, E-2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (1, aequichalcone A), Z-2',6'-dimethoxy-3',4'-(2'',2''-dimethyl)pyranoretrochalcone (2, aequichalcone B), 4''-ethoxy-3''-hydroxypraecansone B (3, aequichalcone C) and a new pterocarpene, 3,4:8,9-dimethylenedioxy-6a,11a-pterocarpene (4), along with seven known compounds were isolated. The purified compounds were characterized by NMR spectroscopic and mass spectrometric analyses. Compound 1 slowly converts into 2 in solution, and thus the latter may have been enriched, or formed, during the extraction and separation process. The isomeric compounds 1 and 2 were both observed in the crude extract. Some of the isolated constituents showed good to moderate antiplasmodial activity against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.
URI
https://www.ncbi.nlm.nih.gov/pubmed/28230755http://www.mdpi.com/1420-3049/22/2/318/htm
http://hdl.handle.net/11295/101131
Citation
Molecules. 2017 Feb 20;22(2). pii: E318. doi: 10.3390/molecules22020318.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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