HIV-1 viral control varies by viral subtype in a large cohort of African adults with incident HIV-1 infection.
dc.contributor.author | Price, MA | |
dc.contributor.author | Rida, W | |
dc.contributor.author | Kilembe, W | |
dc.contributor.author | Karita, E | |
dc.contributor.author | Inambao, M | |
dc.contributor.author | Ruzagira, E | |
dc.contributor.author | Kamali, A | |
dc.contributor.author | Sanders, EJ | |
dc.contributor.author | Anzala, O | |
dc.contributor.author | Hunter, E | |
dc.contributor.author | Allen, S | |
dc.contributor.author | Edward, VA | |
dc.contributor.author | Wall, KM | |
dc.contributor.author | Tang, JS | |
dc.contributor.author | Fast, PE | |
dc.contributor.author | Kaleebu, P | |
dc.contributor.author | Lakhi, S | |
dc.contributor.author | Mutua, G | |
dc.contributor.author | Bekker, LG | |
dc.contributor.author | Abu-Baker, G | |
dc.contributor.author | Tichacek, A | |
dc.contributor.author | Chetty, P | |
dc.contributor.author | Latka, MH | |
dc.contributor.author | Maenetje, P | |
dc.contributor.author | Makkan, H | |
dc.contributor.author | Kibengo, F | |
dc.contributor.author | Priddy, F | |
dc.contributor.author | Gilmour, J | |
dc.date.accessioned | 2019-07-04T10:56:08Z | |
dc.date.available | 2019-07-04T10:56:08Z | |
dc.date.issued | 2019-04-02 | |
dc.identifier.citation | J Infect Dis. 2019 Apr 2 | en_US |
dc.identifier.uri | https://www.ncbi.nlm.nih.gov/pubmed/30938435 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/106528 | |
dc.description.abstract | Few HIV-infected persons can maintain low viral levels without therapeutic intervention. We evaluate predictors of spontaneous viral control in a prospective cohort of African adults shortly after HIV infection. Viral control was defined as ≥2 consecutive VL ≤10,000 copies/mL post-estimated date of infection (EDI) with at least 4 subsequent VL measurements of which at least 75% were ≤ 10,000 in the absence of ART. Multivariable logistic regression characterized predictors of viral control. Of 590 eligible volunteers, 107 (18.1%) experienced viral control of whom 25 (4.2%) maintained VL between 51-2,000 and 5 (0.8%) sustained VL ≤ 50. Median ART free follow-up time was 3.3 years (range: 0.3 to 9.7 years). Factors independently associated with control were HIV-1 subtype A versus C (adjusted odds ratio [aOR]: 2.1 [95%CI: 1.3-3.5]), being female (aOR: 1.8 [1.1-2.8]), and having an HLA class I variant allele B*57 (aOR: 1.9 [1.0-3.6]) in a multivariable model that also controlled for age at time of infection and baseline CD4 T cell count. We observed strong associations between infecting subtype, HLA type, and sex on viral control in this cohort. HIV-1 subtype is important to consider when testing and designing new therapeutic and prevention technologies including vaccines. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Oxford Academic | en_US |
dc.title | HIV-1 viral control varies by viral subtype in a large cohort of African adults with incident HIV-1 infection. | en_US |
dc.type | Article | en_US |
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