dc.contributor.author | Serem, Jared K. | |
dc.contributor.author | Kimani, John M. | |
dc.contributor.author | Wahome, Raphael G. | |
dc.contributor.author | Gakuya, Daniel W. | |
dc.contributor.author | Kiama, Stephen G | |
dc.contributor.author | Onyango, Daniel W. | |
dc.contributor.author | Mbuthia, Paul G. | |
dc.date.accessioned | 2019-08-20T07:03:38Z | |
dc.date.available | 2019-08-20T07:03:38Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Serem, Jared K., et al. "Histopathological Evaluation of Spleen, Liver and Kidneys from Pigs Fed on Moringa oleifera Leaf Meal Diets." (2017). | en_US |
dc.identifier.uri | https://www.researchgate.net/profile/Jared_Serem/publication/322686623_Histopathological_Evaluation_of_Spleen_Liver_and_Kidneys_from_Pigs_Fed_on_Moringa_oleifera_Leaf_Meal_Diets/links/5a68d77c0f7e9b2a828c44a2/Histopathological-Evaluation-of-Spleen-Liver-and-Kidneys-from-Pigs-Fed-on-Moringa-oleifera-Leaf-Meal-Diets.pdf | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/107029 | |
dc.description.abstract | Moringa oleifera leaves and seeds have for a long time been used as food and medicine. Despite
increased usage, little information is available on its application as a nutraceutical agent as well as toxicity.
The objective of this study was to determine the histopathological consequences of prolonged inclusion at
varying levels of Moringa oleifera leaf meal (MOLM) diets on the spleen, liver and kidneys of growing pigs.
Twenty four growing pigs were selected and assigned to four treatment diets (T) containing; 0% (T1), 3% (T2),
6% (T3) and 12% (T4) MOLM concentrations. Each treatment had two replicates of 3 pigs and the experimental
period lasted 7 weeks after which four pigs from each treatment were selected, sacrificed and the spleen, liver
and kidney samples collected for histopathological analysis. The results revealed that increased MOLM in the
diet (>3%) led to the enlargement of splenic follicles (white pulp) as well as capsular and parenchymal fibroses.
In the liver, increased MOLM in the diet led to loss of lobular architecture with damaged cellular outlines,
dilation of sinusoidal spaces, vascular congestion and occasional nuclear changes in hepatocytes leading to
hepatocytic necrosis and distortion of the portal triad. In the kidneys, higher levels of MOLM led to
glomerulonephritis essentially presenting as glomerular oedema leading to reduced Bowman’s space. In the
renal tubules, there appeared to be protein casts in the tubular lumen. In conclusion, prolonged inclusion of
MOLM (>3%) in the diet negatively affected the histoarchitecture of the spleen, liver and the kidneys and may,
in extreme circumstances, result in reduced animal performance. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Hepatotoxic Flavonoids Renal Toxicity Saponins Spleen | en_US |
dc.title | Histopathological Evaluation of Spleen, Liver and Kidneys from Pigs Fed on Moringa oleifera Leaf Meal Diets | en_US |
dc.type | Article | en_US |