Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis
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Date
2017Author
Tsegaye, Deyou
Makungu, Marco
Matthias, Heydenreich
Pan, Fangfang
Amra, Gruhonjic
Fitzpatrick, Paul A.
Andreas, Koch
Solomon, Derese
Jerry, Pelletier
Rissanen, Kari
Abiy, Yenesew
Máté, Erdélyi
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
: A new isoflavone, 8-prenylmilldrone (1), and four
new rotenoids, oblarotenoids A−D (2−5), along with nine known
compounds (6−14), were isolated from the CH2Cl2/CH3OH
(1:1) extract of the leaves of Millettia oblata ssp. teitensis by
chromatographic separation. The purified compounds were
identified by NMR spectroscopic and mass spectrometric analyses,
whereas the absolute configurations of the rotenoids were
established on the basis of chiroptical data and in some cases by
single-crystal X-ray crystallography. Maximaisoflavone J (11) and
oblarotenoid C (4) showed weak activity against the human breast
cancer cell line MDA-MB-231 with IC50 values of 33.3 and 93.8
μM, respectively.
URI
https://pubs.acs.org/doi/abs/10.1021/acs.jnatprod.7b00255https://pubs.acs.org/doi/pdf/10.1021/acs.jnatprod.7b00255?rand=rz0pql5q
http://erepository.uonbi.ac.ke/handle/11295/107094
Citation
Deyou, Tsegaye, et al. "Isoflavones and Rotenoids from the Leaves of Millettia oblata ssp. teitensis." Journal of natural products 80.7 (2017): 2060-2066.Publisher
University of Nairobi
Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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