Effects of the antidepressant drugs clomipramine and mianserin on tryptophan hydroxylase activity in the rat brain, measured at two points in the light/dark cycle
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Date
1994Author
Sinei, Kipruto A.
Redfern, P.H.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Tryptophan hydroxylase activity has been measured in synaptosomal preparations from rat brain. A significant circadian variation in enzyme activity was apparent in corpus striatum, (p < 0.00 I), brainstem and cortex (p < 0.0 I). A single dose of clomipramine or mianserin (20 mg/kg) had no effect on brainstem enzyme activity measured at mid-light or mid-dark. Chronic administration (7.5 rng/kg i.p. twice daily for 2 weeks) of either clomipramine or mianserin significantly increased enzyme activity. There was no significant difference between the drug effects measured at mid-light or mid-dark.
URI
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/10784http://www.ncbi.nlm.nih.gov/pubmed/8013048
Citation
Chronobiology International Vol. II, No. I, pp. 27-34Publisher
Pharmacology Group, School of Pharmacy and Pharmacology, University of Bath, Bath, England
Collections
- Faculty of Health Sciences (FHS) [10378]