dc.contributor.author | Baeten, JM | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Martin, HL | |
dc.contributor.author | Nyange, PM | |
dc.contributor.author | Lavreys, L | |
dc.contributor.author | Ngugi, Elizabeth N | |
dc.contributor.author | Mandaliya, K | |
dc.contributor.author | Ndinya-Achola, JO | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Kreiss, JK | |
dc.date.accessioned | 2013-02-28T09:10:55Z | |
dc.date.issued | 2000 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/12265 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/11035617 | |
dc.description.abstract | Background: Accurate predictions of HIV-I incidence in potential study populations are essential for designing HIV-I vaccine efficacy trials. Lillie information is available on the estimated incidence of HIV-I in such populations. especially information on incidence over time and incidence while participating in risk-reduction programs.
Objectives: To examine time trends in HIV-I incidence in a vaccine preparedness cohort.
Design: Prospective cohort study of female prostitutes in Momhasn, Kenya. Methods: HIV -I incidence was determined using open and closed coll.".1 desig'''.
Generalized estimating equations were used to model HIV -I und sexually trunsmittcd disease (STD) incidence and sexual risk behaviors over time.
Results: When analyzed as a closed cohort, HIV-I incidence dcclincdjlO-l"old during 3 years of follow-up (from 17.4 to 1.7 cases/I 00 person-years: I' < .OOr). More than 50% of the cases of mV-1 occurred during the first 6 months after enrollment. and 73% during the first 12 months. When analyzed as an open whorl. lilY -I incidence density fell during the first 4 calendar years, influenced hy accumulation of lower risk participants and variations in study recruitment. Si!,!nilil';rnt declines occurred in both STD incidence and high-risk sexual behaviors during follow-up.
Conclusions: This study documents a dramatic decline in the risk of IllY-I infection while participating in a prospective cohort, with most seroconvcrsions occurring within I year of enrollment. Variations in HIV-I incidence within high-risk populations should be anticipated during the design of vaccine trials. | en |
dc.language.iso | en | en |
dc.subject | HIV-I incidence | en |
dc.subject | Vaccine | en |
dc.subject | Prostitutes | en |
dc.subject | Sexual | en |
dc.subject | Behavior | en |
dc.subject | STD | en |
dc.subject | Africa | en |
dc.title | Trends in HIV -1 Incidence in a Cohort of Prostitutes in Kenya: Implications for HIV -1 Vaccine Efficacy Trials | en |
dc.type | Article | en |
local.publisher | Department of Community Health, University of Nairobi | en |