Browsing College of Agriculture and Veterinary Sciences (CAVS) by Author "Louisse, Jochem"

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Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry.

Kanja, Laetitia; Omwenga, Isaac; Zhao, Shensheng; Mol, Hans; Rietjens, Ivonne M. C. M.; Louisse, Jochem (University of Nairobi, 2021)

Organophosphate pesticides (OPs) are known to inhibit acetylcholine esterase (AChE), a critical effect used to establish health-based guidance values. This study developed a combined in vitro–in silico approach to predict ...