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The origins of a research community in the Majengo observational cohort study, Nairobi, Kenya
(2010-10-21)
Abstract
Background
Since the 1980s the Majengo Observational Cohort Study (MOCS) has examined sexually transmitted infections, in ...
CD26/ dipeptidyl peptidase IV (CD26/DPPIV) is highly expressed in peripheral blood of HIV-1 exposed uninfected Female sex workers
(2010-11-25)
Abstract
Background
Design of effective vaccines against the human immunodeficiency virus (HIV-1) continues to present formidable challenges. However, individuals who are exposed HIV-1 but do not get infected may reveal ...
Age and menopause affect the expression of specific cytokines/chemokines in plasma and cervical lavage samples from female sex workers in Nairobi, Kenya
(2013-10-22)
Aging of the immune system, known as immunosenescence, is associated with profound changes in both innate and adaptive immune responses, resulting in increased susceptibility to infection and a decreased ability to respond ...
'Relief of oppression': An organizing principle for researchers' obligations to participants in observational studies in the developing world
(2010-06-30)
Abstract
Background
A central question in the debate about exploitation in international research is whether investigators and ...
Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial
(2012-10-31)
Abstract
Background
Children are most vulnerable to malaria. A pyronaridine-artesunate pediatric granule formulation is being developed for the treatment of uncomplicated Plasmodium falciparum ...
Prevalence and risk factors of three curable sexually transmitted infections among women in Nairobi, Kenya
(http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4812604/, 2016-03)
Background
Sexually transmitted infections (STIs) are a major public health problem, especially in developing countries. The complications of untreated STIs in the female genital tract and their role in adverse pregnancy ...
Prevention of mother-to-child transmission of HIV in Kenya: challenges to implementation
(University of Nairobi,, 2014)
Background
The prevention of mother-to-child transmission of human immunodeficiency virus (HIV) is lauded as one of the more successful HIV prevention measures. However, despite some gains in the prevention of mother-to-child ...
The role of G Protein Gene GNB3 C825T Polymorphism in HIV-1 acquisition, progression and immune activation
(2012-01-03)
Abstract
Background
The GNB3 C825T polymorphism is associated with increased G protein-mediated signal transduction, SDF-1α-mediated lymphocyte chemotaxis, accelerated HIV-1 progression, and altered responses to ...