Browsing Biomed Full Text Articles by Author "Kimani, Joshua"
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Age and menopause affect the expression of specific cytokines/chemokines in plasma and cervical lavage samples from female sex workers in Nairobi, Kenya
Sivro, Aida; Lajoie, Julie; Kimani, Joshua; Jaoko, Walter; Plummer, Francis A; Fowke, Keith; Ball, T B (2013-10-22)Aging of the immune system, known as immunosenescence, is associated with profound changes in both innate and adaptive immune responses, resulting in increased susceptibility to infection and a decreased ability to respond ... -
CD26/ dipeptidyl peptidase IV (CD26/DPPIV) is highly expressed in peripheral blood of HIV-1 exposed uninfected Female sex workers
Songok, Elijah M; Osero, Bernard; Mckinnon, Lyle; Rono, Martin K; Apidi, Winnie; Matey, Elizabeth J; Meyers, Adrienne FA; Luo, Ma; Kimani, Joshua; Wachihi, Charles; Ball, Blake T; Plummer, Frank A; Mpoke, Solomon (2010-11-25)Abstract Background Design of effective vaccines against the human immunodeficiency virus (HIV-1) continues to present formidable challenges. However, individuals who are exposed HIV-1 but do not get infected may reveal ... -
The frequencies of naturally occurring protease inhibitor resistance mutations in HIV proviral sequences of drug naïve sex workers in Nairobi, Kenya and their correlation with host immune response driven positively selected mutations in HIV-1
Sampathkumar, Raghavan; Elnaz, Shadabi; David, LA; John, H; Binhua, Liang; Kimani, Joshua; Francis, A Plummer; Luo, MA (University of Nairobi,, 2014) -
Prevention of mother-to-child transmission of HIV in Kenya: challenges to implementation
Elsabé du, Plessis; Souradet, Y Shaw; Gichuhi, Mary; Larry, Gelmon; Bensen, B Estambale; Richard, Lester; Kimani, Joshua; Lisa, S Avery (University of Nairobi,, 2014)Background The prevention of mother-to-child transmission of human immunodeficiency virus (HIV) is lauded as one of the more successful HIV prevention measures. However, despite some gains in the prevention of mother-to-child ... -
Pyronaridine-artesunate granules versus artemether-lumefantrine crushed tablets in children with Plasmodium falciparum malaria: a randomized controlled trial
Kayentao, Kassoum; Doumbo, Ogobara K; Pénali, Louis K; Offianan, André T; Bhatt, KM; Kimani, Joshua; Tshefu, Antoinette K; Kokolomami, Jack HT; Ramharter, Michael; de Salazar, Pablo Martinez; Tiono, Alfred B; Ouédraogo, Alphonse; Bustos, Maria Dorina G; Quicho, Frederick; Borghini-Fuhrer, Isabelle; Duparc, Stephan; Shin, Chang-Sik; Fleckenstein, Lawrence (2012-10-31)Abstract Background Children are most vulnerable to malaria. A pyronaridine-artesunate pediatric granule formulation is being developed for the treatment of uncomplicated Plasmodium falciparum ... -
'Relief of oppression': An organizing principle for researchers' obligations to participants in observational studies in the developing world
Lavery, James V; Bandewar, Sunita VS; Kimani, Joshua; Upshur, Ross EG; Plummer, Frances A; Singer, Peter A (2010-06-30)Abstract Background A central question in the debate about exploitation in international research is whether investigators and ... -
The origins of a research community in the Majengo observational cohort study, Nairobi, Kenya
Bandewar, Sunita VS; Kimani, Joshua; Lavery, James V (2010-10-21)Abstract Background Since the 1980s the Majengo Observational Cohort Study (MOCS) has examined sexually transmitted infections, in ... -
The role of G Protein Gene GNB3 C825T Polymorphism in HIV-1 acquisition, progression and immune activation
Juno, Jennifer; Tuff, Jeffrey; Choi, Robert; Card, Catherine; Kimani, Joshua; Wachihi, Charles; Koesters-Kiazyk, Sandra; Ball, T Blake; Farquhar, Carey; Plummer, Francis A; John-Stewart, Grace; Luo, Ma; Fowke, Keith R (2012-01-03)Abstract Background The GNB3 C825T polymorphism is associated with increased G protein-mediated signal transduction, SDF-1α-mediated lymphocyte chemotaxis, accelerated HIV-1 progression, and altered responses to ...