Browsing Biomed Full Text Articles by Author "Kokwaro, Gilbert"
Now showing items 1-4 of 4
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A phase I trial to evaluate the safety and pharmacokinetics of low-dose methotrexate as an anti-malarial drug in Kenyan adult healthy volunteers
Chilengi, Roma; Juma, Rashid; Abdallah, Ahmed M; Bashraheil, Mahfudh; Lodenyo, Hudson; Nyakundi, Priscilla; Anabwani, Evelyn; Salim, Amina; Mwambingu, Gabriel; Wenwa, Ednah; Jemutai, Julie; Kipkeu, Chemtai; Oyoo, George O; Muchohi, Simon N; Kokwaro, Gilbert; Niehues, Tim; Lang, Trudie; Nzila, Alexis (2011-03-16)Abstract Background Previous investigations indicate that methotrexate, an old anticancer drug, could be used at low doses to treat malaria. A phase I evaluation was conducted to assess the safety and pharmacokinetic ... -
Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia
Teka, Hiwot; Petros, Beyene; Yamuah, Lawrence; Tesfaye, Gezahegn; Elhassan, Ibrahim; Muchohi, Simon; Kokwaro, Gilbert; Aseffa, Abraham; Engers, Howard (2008-10-29)Abstract Background Plasmodium vivax accounts for about 40% of all malaria infection in Ethiopia. Chloroquine (CQ) is the ... -
Pentoxifylline as an adjunct therapy in children with cerebral malaria
Lell, Bertrand; Köhler, Carsten; Wamola, Betty; Olola, Christopher HO; Kivaya, Esther; Kokwaro, Gilbert; Wypij, David; Mithwani, Sadik; Taylor, Terrie E; Kremsner, Peter G; Newton, Charles RJC (2010-12-21)Abstract Background Pentoxifylline (PTX) affects many processes that may contribute to the pathogenesis of severe malaria and it has been shown to reduce the duration of coma in children with cerebral malaria. This pilot ... -
The content of African diets is adequate to achieve optimal efficacy with fixed-dose artemether-lumefantrine: a review of the evidence
Premji, Zulfiqarali G; Abdulla, Salim; Ogutu, Bernhards; Ndong, Alice; Falade, Catherine O; Sagara, Issaka; Mulure, Nathan; Nwaiwu, Obiyo; Kokwaro, Gilbert (2008-11-25)Abstract A fixed-dose combination of artemether-lumefantrine (AL, Artemas®) has shown high efficacy, good tolerability and cost-effectiveness in adults and children with uncomplicated malaria caused by Plasmodium ...