dc.contributor.author | Graham, Susan M | |
dc.contributor.author | Baeten, Jared M | |
dc.contributor.author | Richardson, Barbra A | |
dc.contributor.author | Bankson, Daniel D | |
dc.contributor.author | Lavreys, Ludo | |
dc.contributor.author | Ndinya-Achola JO | |
dc.contributor.author | Mandaliya, Kishorchandra | |
dc.contributor.author | Overbaugh, Julie | |
dc.contributor.author | McClelland, R Scott | |
dc.date.accessioned | 2013-03-19T16:16:26Z | |
dc.date.available | 2013-03-19T16:16:26Z | |
dc.date.issued | 2007-06-26 | |
dc.identifier.citation | BMC Infectious Diseases. 2007 Jun 26;7(1):63 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/17594484 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/14769 | |
dc.description.abstract | Abstract
Background
Low vitamin E levels are often found in HIV-1 infection, and studies have suggested that higher levels may decrease the risk of disease progression. However, vitamin E supplementation has also been reported to increase CCR5 expression, which could increase HIV-1 replication. We hypothesized that vitamin E levels at HIV-1 acquisition may influence disease progression.
Methods
Vitamin E status was measured in stored samples from the last pre-infection visit for 67 Kenyan women with reliably estimated dates of HIV-1 acquisition. Regression analyses were used to estimate associations between pre-infection vitamin E and plasma viral load, time to CD4 count <200 cells/μL, and mortality.
Results
After controlling for potential confounding factors, each 1 mg/L increase in pre-infection vitamin E was associated with 0.08 log10 copies/mL (95% CI -0.01 to +0.17) higher set point viral load and 1.58-fold higher risk of mortality (95% CI 1.15–2.16). The association between higher pre-infection vitamin E and mortality persisted after adjustment for set point viral load (HR 1.55, 95% CI 1.13–2.13).
Conclusion
Higher pre-infection vitamin E levels were associated with increased mortality. Further research is needed to elucidate the role vitamin E plays in HIV-1 pathogenesis. | |
dc.title | Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective study | |
dc.type | Journal Article | |
dc.date.updated | 2013-03-19T16:16:26Z | |
dc.description.version | Peer Reviewed | |
dc.language.rfc3066 | en | |
dc.rights.holder | Susan M Graham et al.; licensee BioMed Central Ltd. | |