Antioxidant and anti-inflammatory activities of selected medicinal plants from western Kenya
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Date
2017-12Author
Odongo, Elizabeth
Mungai, Nelly
Mutai, Peggoty
Karumi, Esther
Mwangi, Julius
Okalebo a, Faith
Kimondo, Julia
Omale, Joseph
Simiyu, Juma
Type
ArticleLanguage
en_USMetadata
Show full item recordAbstract
Background: Globally, the increase in the burden of diseases related to oxidative damage and inflammation, coupled
with the high cost of medication and the side effects of these therapies necessitates a need for more effective,
affordable and safer remedies. Thus there still exists a demand for new antioxidant and anti-inflammatory agents.
Objectives: To screen selected medicinal plants from Kakamega County for their antioxidant and anti-inflammatory
activities.
Methodology: Seven medicinal plants used to treat ailments related to oxidative damage and inflammation were
selected and extraction was carried out using methanol. Antioxidant activity was screened using 2, 2-diphenyl-1-
picrylhydrazyl assay while carrageenan induced rat paw edema assay was used to screen for their anti-inflammatory
activity.
Results: The methanolic leaf extracts of Rhus vulgaris and Phyllanthus fischeri displayed good antioxidant activity with
percentage inhibition of 71.4% and 66.7 % respectively. Furthermore, the methanolic leaf extract of Rhus vulgaris
displayed significant anti-inflammatory activity while Phyllanthus fischeri had mild activity. Results were considered
to be statistically significant when (P<0.05).
Conclusion: These results support the use of Rhus vulgaris and Phyllanthus fischeri in traditional medicine to remedy
oxidative damage and inflammatory related diseases. These two plants are potential sources of natural antioxidant
and anti-inflammatory agents.
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file:///C:/Users/223640/Downloads/1686-5906-1-PB.pdfhttp://erepository.uonbi.ac.ke/handle/11295/152842
Citation
Odongo, E., Mungai, N., Mutai, P., Karumi, E., Mwangi, J., Okalebo, F., ... & Simiyu, J. (2017). Antioxidant and anti-inflammatory activities of selected medicinal plants from western Kenya. African Journal of Pharmacology and Therapeutics, 6(4).Publisher
KeSoBAP
Collections
- Faculty of Health Sciences (FHS) [10378]