Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke
Date
2020Author
Owor, Richard O
Gebreheiwot Bedane, Kibrom
Openda, Yolande I
Zühlke, Sebastian
Derese, Solomon
Ong'amo, George
Ndakala, Albert
Spiteller, Michael
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
A new flavone, named hildeflavone (1) along with 7 other known flavonoids were isolated from the aerial parts of Tephrosia hildebrandtii Vatke. Their characterisation was based on NMR and MS data analysis. The anti-inflammatory properties of the crude extract, isolated compounds and combination of the compounds were investigated in lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells (PBMCs). Treatment of the LPS-stimulated PBMCs with the isolated flavonoids at a concentration of 100 µM significantly reduced the production of interleukins (IL-1β, IL-2 and IL-6), interferon-gamma (IFN-γ), granulocyte macrophage-colony stimulating factor (GM-CSF) and tumour necrosis factor-alpha (TNF-α). It was also found that the combination of a flavone and flavanones exhibited remarkable synergistic anti-inflammatory effects on the production of the cytokines.
Citation
Owor RO, Bedane KG, Openda YI, Zühlke S, Derese S, Ong'amo G, Ndakala A, Spiteller M. Synergistic anti-inflammatory activities of a new flavone and other flavonoids from Tephrosia hildebrandtii vatke. Nat Prod Res. 2020 Mar 31:1-8. doi: 10.1080/14786419.2020.1736065. Epub ahead of print. PMID: 32233673.Publisher
University of Nairobi
Subject
Fabaceae; Tephrosia hildebrandtii; anti-inflammatory; cytokine; flavonoid; hildeflavone; synergy.Rights
Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
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