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dc.contributor.authorBabiaka, Smith B.
dc.contributor.authorRene, Nia
dc.contributor.authorAbuga, Kennedy O.
dc.contributor.authorMbah, James A.
dc.contributor.authorNziko, Vincent de Paul N.
dc.contributor.authorPaper, Dietrich H.
dc.contributor.authorNtie-Kang, Fidele
dc.identifier.citationBabiaka SB, Nia R, Abuga KO, Mbah JA, Nziko VN, Paper DH, Ntie-Kang F. "Antioxidant potential of flavonoid glycosides from Manniophyton fulvum Müll. (Euphorbiaceae): Identification and molecular modeling." Scientic African. 2020;8(e00423):1-7.en_US
dc.description.abstractChemical investigation of the leaves of Manniophyton fulvum led to the isolation of seven flavonoid glycosides: myricetin-3- O - β- Dd -rhamnoside ( 1 ), kaempferol-3- O - β- d -rhamnoside ( 2 ), quercetin-3- O - β- d -glucoside ( 3 ), quercetin-3- O - β- d -rhamnoside ( 4 ), quercetin-3- O - β- d -galactoside ( 5 ), rutin ( 6) and quercetin ( 7 ). The structures of the com- pounds were established by spectroscopic analyses as well as by comparison with pub- lished data. Some of the compounds showed strong antioxidant activity which validates the traditional use of the plant. An attempted correlation between the computed HOMO- LUMO energies and the measured antioxidant activities was established. We have also es- timated the cardiotoxicity of the compounds by calculating the predicted logarithm of the human Ether-‘a-go-go Related Gene (loghERG) using the QikProp program. These purified flavonoids are new potential lead compounds for the development of antioxidant drugsen_US
dc.publisherUniversity of Nairobien_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.subjectAntioxidant and anti-inflammatory Flavonoid glycosides Manniophyton fulvum HERG Molecular modelingen_US
dc.titleAntioxidant Potential of Flavonoid Glycosides From Manniophyton Fulvum Müll. (Euphorbiaceae): Identification and Molecular Modelingen_US

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