dc.contributor.author | Awori, M | |
dc.contributor.author | Mehta, N. | |
dc.contributor.author | Kebba, N. | |
dc.contributor.author | Makori, E | |
dc.date.accessioned | 2021-01-06T08:51:38Z | |
dc.date.available | 2021-01-06T08:51:38Z | |
dc.date.issued | 2020-05-21 | |
dc.identifier.citation | Awori, M., Mehta, N., Kebba, N., & Makori, E. (2020). Adding Blood to St Thomas Solution Does Not Improve Mortality in Pediatric Cardiac Surgery: A Meta-analysis of a Homogenous Population. Annals of African Surgery, 17(2), 60-64. | en_US |
dc.identifier.issn | 1999-9674 | |
dc.identifier.uri | https://www.ajol.info/index.php/aas/article/view/196056 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/153576 | |
dc.description.abstract | Background: Cardioplegia is the gold standard for providing ideal operating conditions while effecting myocardial protection. Some studies suggest that adding blood to St Thomas cardioplegia solution improves efficacy; this is generally accepted as true. However, the few meta-analyses conducted on children have pooled heterogeneous populations; this raises concern about the validity of their conclusions. Methods: PUBMED, the Cochrane Library and Google Scholar were searched systematically until March 2019 using the search terms “cardioplegia”; “myocardial protection”; “pediatric” “pediatric”; “children”; “infants”; “neonates”. Full text articles were examined if abstracts revealed that the studies possibly contained a blood cardioplegia arm and a crystalloid cardioplegia arm. Studies were included in the meta-analysis if they had a 4:1 blood cardioplegia arm and a St Thomas solution arm. Meta-analysis was performed using Meta-Mar software. Results: The search retrieved 423 articles; 5 were included in the meta-analysis, representing 324 patients. The risk ratio for operative mortality was 0.77(95% CI 0.24–2.5; p=0.66). Little evidence was seen of heterogeneity of the pooled patients. Conclusion: Adding blood to St Thomas cardioplegia solution did not improve in-hospital operative mortality; this may have implications for use of blood cardioplegia | en_US |
dc.description.abstract | Background: Cardioplegia is the gold standard for providing ideal operating conditions while effecting myocardial protection. Some studies suggest that adding blood to St Thomas cardioplegia solution improves efficacy; this is generally accepted as true. However, the few meta-analyses conducted on children have pooled heterogeneous populations; this raises concern about the validity of their conclusions. Methods: PUBMED, the Cochrane Library and Google Scholar were searched systematically until March 2019 using the search terms “cardioplegia”; “myocardial protection”; “pediatric” “pediatric”; “children”; “infants”; “neonates”. Full text articles were examined if abstracts revealed that the studies possibly contained a blood cardioplegia arm and a crystalloid cardioplegia arm. Studies were included in the meta-analysis if they had a 4:1 blood cardioplegia arm and a St Thomas solution arm. Meta-analysis was performed using Meta-Mar software. Results: The search retrieved 423 articles; 5 were included in the meta-analysis, representing 324 patients. The risk ratio for operative mortality was 0.77(95% CI 0.24–2.5; p=0.66). Little evidence was seen of heterogeneity of the pooled patients. Conclusion: Adding blood to St Thomas cardioplegia solution did not improve in-hospital operative mortality; this may have implications for use of blood cardioplegia | en_US |
dc.language.iso | en | en_US |
dc.publisher | Ann Afr Surg | en_US |
dc.subject | Cardioplegia, Pediatric, Congenital heart surgery, Mortality, Meta-analysis | en_US |
dc.subject | Cardioplegia, Pediatric, Congenital heart surgery, Mortality, Meta-analysis | en_US |
dc.title | Adding blood to st thomas solution does not improve mortality in pediatric cardiac surgery: a meta-analysis of a homogenous population | en_US |
dc.type | Article | en_US |