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Zika Virus Circulates at Low Levels in Western and Coastal Kenya

dc.contributor.authorGobillot, Theodore A
dc.contributor.authorKikawa, Caroline
dc.contributor.authorLehman, Dara A
dc.contributor.authorKinuthia, John
dc.contributor.authorDrake, Alison L
dc.contributor.authorJaoko, Walter
dc.contributor.authorMandaliya, Kishorchandra
dc.contributor.authorJohn-Stewart, Grace
dc.contributor.authorMcClelland, R Scott
dc.contributor.authorOverbaugh, Julie
dc.date.accessioned2021-01-18T12:14:01Z
dc.date.available2021-01-18T12:14:01Z
dc.date.issued2020
dc.identifier.citationGobillot TA, Kikawa C, Lehman DA, Kinuthia J, Drake AL, Jaoko W, Mandaliya K, John-Stewart G, McClelland RS, Overbaugh J. Zika Virus Circulates at Low Levels in Western and Coastal Kenya. J Infect Dis. 2020 Aug 4;222(5):847-852. doi: 10.1093/infdis/jiaa158. PMID: 32242626; PMCID: PMC7399697.en_US
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/32242626/
dc.identifier.urihttp://erepository.uonbi.ac.ke/handle/11295/153614
dc.description.abstractBackground: Zika virus (ZIKV) was discovered over 70 years ago in East Africa, but little is known about its circulation and pathogenesis there. Methods: We screened 327 plasma samples collected 2-12 months after febrile illness in Western and coastal Kenya (1993-2016) for binding and neutralizing antibodies to distinguish ZIKV and dengue virus (DENV) responses, which we found were common in coastal Kenya. Results: Two cases had durable ZIKV-specific antibodies and 2 cases had ZIKV antibodies at similar levels as DENV antibodies. Conclusions: This suggests low-level ZIKV circulation in Kenya over 2 decades and sets a baseline for future surveillance efforts in East Africa.en_US
dc.language.isoenen_US
dc.publisherUniversity of Nairobien_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectKenya; Zika virus; arbovirus; seroprevalence.en_US
dc.titleZika Virus Circulates at Low Levels in Western and Coastal Kenyaen_US
dc.typeArticleen_US


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