dc.contributor.author | Osoti, Alfred O | |
dc.contributor.author | Page, Stephanie T | |
dc.contributor.author | Richardson, Barbra A | |
dc.contributor.author | Guthrie, Brandon L | |
dc.contributor.author | Kinuthia, John | |
dc.contributor.author | Polyak, Stephen J | |
dc.contributor.author | Farquhar, Carey | |
dc.date.accessioned | 2021-08-27T12:46:43Z | |
dc.date.available | 2021-08-27T12:46:43Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Osoti AO, Page ST, Richardson BA, Guthrie BL, Kinuthia J, Polyak SJ, Farquhar C. Postpartum metabolic syndrome and high-sensitivity C-reactive protein after gestational hypertension and pre-eclampsia. Int J Gynaecol Obstet. 2020 Dec;151(3):443-449. doi: 10.1002/ijgo.13352. Epub 2020 Sep 16. PMID: 32812650; PMCID: PMC7722223. | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/32812650/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/155364 | |
dc.description.abstract | Objective: To evaluate the association between metabolic syndrome (MetS) and high-sensitivity C-reactive protein (hsCRP), a biomarker of chronic inflammation and an independent predictor for cardiovascular disease overall and in subgroups of women with/without pre-eclampsia and gestational hypertension (GHT).
Methods: A prospective cohort study was conducted in Nairobi, Kenya. Women with pre-eclampsia or GHT and normotensive women within 12 weeks postpartum underwent physical, anthropometric, fasting lipid profile, plasma glucose, and hsCRP measurements at 6 months postpartum. A generalized linear regression model with Poisson distribution adjusted for body mass index and age was used to estimate the association between elevated hsCRP and MetS overall and stratified by pre-eclampsia or GHT.
Results: In the 171 women included in the study, risk of elevated hsCRP (>3 mg/L) was greater among women with compared to those without MetS (adjusted relative risk [ARR] 1.70, 95% confidence interval [CI] 1.05-2.73, P=0.03) and was statistically significantly higher in the hypertensive (ARR 2.16 95% CI 1.01-4.62, P=0.04) but not in the normotensive (ARR 1.46, 95% CI 0.93-2.28) group.
Conclusion: Increased risk of elevated hsCRP postpartum can guide longitudinal mechanistic and intervention studies to reduce postpartum cardiovascular morbidity in women with MetS, especially after pre-eclampsia or GHT.
Keywords: Cardiovascular; Gestational; High-sensitivity C-reactive protein; Metabolic syndrome; Postpartum; Pre-eclampsia. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Cardiovascular; Gestational; High-sensitivity C-reactive protein; Metabolic syndrome; Postpartum; Pre-eclampsia. | en_US |
dc.title | Postpartum metabolic syndrome and high-sensitivity C-reactive protein after gestational hypertension and pre-eclampsia | en_US |
dc.type | Article | en_US |