Formulation of Hydroalcoholic Gel With 80% Isopropyl Alcohol

Abstract

Background: Hydro alcoholic gels are used as hand disinfectants to kill microbes on the skin. Most of hydro alcoholic gels contain a WHO recommended alcohol concentration with a range of 60% to 95% which destroys the lipid that contains the cell membrane of the bacteria and fungi. Besides, alcohol denatures the proteins and enzymes inside bacteria and fungi. Alcohol also dissolves capsids of viruses. Methodology: This study sought to develop a hydro alcoholic gel composed of carbopol 934 polymer, hydrogen peroxide, isopropyl alcohol, purified water or deionized water and glycerol using the direct addition method. To assess the quality of the formulated product analytical tests such as appearance, viscosity, pH, assay of isopropyl alcohol and stability were determined. Results and discussion: A well calibrated equipment were used to determine the critical tests, the three formulated hydro-alcoholic gel which are clear colorless gels. Their pH varied from 5.8 to 6.4, their viscosity was tested using an SP 9 at the same RPM and same TO and all the three sample were found to be in the standardized range of 800 – 45000 centipoise, using a chromatographic technique (GC) the assay was done and the three samples were presented as follows respectively 78%, 82% and 76%. Conclusion: Therefore, in my view, it would appear that P3 can answer to this need; furthermore, it would be valuable to carry on the trials with the purpose to assess the optimum ratio of alcohol to moisturizers (with the least possible amount of alcohol) that provides the greatest antimicrobial activity.