dc.contributor.author | Masila, Veronica M | |
dc.contributor.author | Ndakala, Albert J | |
dc.contributor.author | Midiwo, Jacob O | |
dc.contributor.author | Byamukama, Robert | |
dc.contributor.author | Kamau, Rahab W | |
dc.contributor.author | Kumarihamy, Mallika | |
dc.contributor.author | Muhammad, Ilias | |
dc.date.accessioned | 2022-07-07T08:44:30Z | |
dc.date.available | 2022-07-07T08:44:30Z | |
dc.date.issued | 2022-05 | |
dc.identifier.citation | Masila VM, Ndakala AJ, Midiwo JO, Byamukama R, Kamau RW, Kumarihamy M, Muhammad I. Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties. Nat Prod Res. 2022 May;36(9):2321-2328. doi: 10.1080/14786419.2020.1833201. Epub 2020 Oct 24. PMID: 33103456. | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/33103456/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/161262 | |
dc.description.abstract | Monoterpene derivatives are of great biological relevance in the pharmaceutical industry. In the present study, pyrrolidine derivative of a carvotacetone, 3-O-benzylcarvotacetone (1), and selected monoterpenes (3-hydroxy-2-isopropyl-5-methyl-p-benzoquinone (3) and cis-piperitol (5)) were prepared to provide (R)-1-(4-(benzyloxy)-5-isopropyl-2-methylcyclohexa-1,3-dien-1-yl)-pyrrolidine (2), 2-isopropyl-5-methyl-3,6-dioxocyclohexa-1,4-dien-1-yl acetate (4), cis-3-hydroxypiperitone (6) and carvacrol (7). Structure of 2 was determined based on NMR and HRMS spectral data. Compound 4 exhibited activity against fungi Cryptococcus neoformans with an IC50 value of < 0.8 µg/mL. In addition, this compound 4 had an IC50 value of 14.97 µg/mL against methicillin resistant Staphylococcus aureus bacteria. Previous to the current study, both compound 6 and 7 had been reported to have anti-microbial and anti-fungal activities. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Anti-MRSA; Anti-cryptococcal; Carvacrol; Cis-3-hydroxypiperitone; Monoterpenes. | en_US |
dc.title | Synthesis of a pyrrolidine derivative of a carvotacetone and monoterpenes for anti-methicillin-resistant Staphylococcus aureus and anti-cryptococcal properties | en_US |
dc.type | Article | en_US |