Quality of metronidazole benzoate suspension products marketed in Nairobi County, Kenya
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Date
2022-09-06Author
Odoyo, A. O.
Abuga, K. O.
Mugo, H. N.
Mang'oi, J. S
Type
ArticleLanguage
en_USMetadata
Show full item recordAbstract
Metronidazole benzoate is an ester derivative of metronidazole utilized in the
formulation of oral suspensions owing to its palatability. The drug is liable to
hydrolytic degradation during shelf life which could lower assay values and increase
free metronidazole content. A medicine quality survey study was carried out in
Nairobi County whereby 32 metronidazole benzoate samples representing 13 brands
were collected from retail pharmacies. The samples were subjected to British
Pharmacopoeia specifications for pH, free metronidazole content and assay. From
the results obtained, only nine samples (28.1%) passed all the quality tests performed
while five (15.6%), seven (21.9%) and 18 (56.3%) did not comply with pH,
metronidazole content and assay specifications respectively. The results obtained
demonstrate the existence of substandard metronidazole benzoate products in the
market. This underscores the need for regular post market surveillance surveys and
execution of appropriate regulatory actions
URI
http://uonjournals.uonbi.ac.ke/ojs/index.php/ecajps/article/view/1102http://erepository.uonbi.ac.ke/handle/11295/161406
Citation
Odoyo, A. O., Abuga, K. O., Mugo, H. N., & Mang'oi, J. S. (2021). Quality of Metronidazole Benzoate Suspension Products Marketed in Nairobi County, Kenya. The East and Central African Journal of Pharmaceutical Sciences, 24(3), 131-135.Publisher
East Cent. Afr. J. Pharm. Sci
Subject
Quality control, assay, metronidazole content, pH, substandard and falsified medicine, degradationCollections
- Faculty of Health Sciences (FHS) [10378]