Anti-HIV crotocascarin ω from Kenyan Croton dichogamus
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Date
2022-10Author
Terefe, Ermias M
Okalebo, Faith A
Derese, Solomon
Muriuki, Joseph
Mas-Claret, Eduard
Langat, Moses K
Type
ArticleLanguage
enMetadata
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An anti-HIV methanol-soluble fraction of a 1:1 CH2Cl2:CH3OH extract of twigs of a Kenyan Croton dichogamus yielded seven compounds, the new crotocascarin ω (1), the known β-oplopanone (2), dihydroconiferyl acetate (3), 3'(4''-hydroxyphenyl)-propyl benzoate (4), lupeol, sitosterol and stigmasterol. Crotocascarin ω (90%) inhibited HIV-1 replication with an IC50 value of 5.3 nM, and the compound was cytotoxic towards MT-4 cells presenting an IC50 value of 84 µM. In silico modelling showed that the anti-HIV activity for compound 1 could be through the HIV-1 protease inhibition.
Citation
Terefe EM, Okalebo FA, Derese S, Muriuki J, Mas-Claret E, Langat MK. Anti-HIV crotocascarin ω from Kenyan Croton dichogamus. Nat Prod Res. 2022 Oct 24:1-8. doi: 10.1080/14786419.2022.2134998. Epub ahead of print. PMID: 36278900.Publisher
University of Nairobi
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Attribution-NonCommercial-NoDerivs 3.0 United StatesUsage Rights
http://creativecommons.org/licenses/by-nc-nd/3.0/us/Collections
- Faculty of Health Sciences (FHS) [10378]
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