dc.contributor.author | Terefe, Ermias M | |
dc.contributor.author | Okalebo, Faith A | |
dc.contributor.author | Derese, Solomon | |
dc.contributor.author | Muriuki, Joseph | |
dc.contributor.author | Mas-Claret, Eduard | |
dc.contributor.author | Langat, Moses K | |
dc.date.accessioned | 2022-11-09T07:17:24Z | |
dc.date.available | 2022-11-09T07:17:24Z | |
dc.date.issued | 2022-10 | |
dc.identifier.citation | Terefe EM, Okalebo FA, Derese S, Muriuki J, Mas-Claret E, Langat MK. Anti-HIV crotocascarin ω from Kenyan Croton dichogamus. Nat Prod Res. 2022 Oct 24:1-8. doi: 10.1080/14786419.2022.2134998. Epub ahead of print. PMID: 36278900. | en_US |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/161657 | |
dc.description.abstract | An anti-HIV methanol-soluble fraction of a 1:1 CH2Cl2:CH3OH extract of twigs of a Kenyan Croton dichogamus yielded seven compounds, the new crotocascarin ω (1), the known β-oplopanone (2), dihydroconiferyl acetate (3), 3'(4''-hydroxyphenyl)-propyl benzoate (4), lupeol, sitosterol and stigmasterol. Crotocascarin ω (90%) inhibited HIV-1 replication with an IC50 value of 5.3 nM, and the compound was cytotoxic towards MT-4 cells presenting an IC50 value of 84 µM. In silico modelling showed that the anti-HIV activity for compound 1 could be through the HIV-1 protease inhibition. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | 3’(4’’-hydroxyphenyl)-propyl benzoate; Anti-HIV activity; Croton dichogamus; crotocascarin ω; dihydroconiferyl acetate; β-oplopanone. | en_US |
dc.title | Anti-HIV crotocascarin ω from Kenyan Croton dichogamus | en_US |
dc.type | Article | en_US |