dc.contributor.author | Slyker, Jennifer A | |
dc.contributor.author | Lohman, Barbara L | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | Reilly, Marie | |
dc.contributor.author | Wee, Edmund G T | |
dc.contributor.author | Dong, Tao | |
dc.contributor.author | McMichael, Andrew J | |
dc.contributor.author | Rowland-Jones, Sarah L | |
dc.contributor.author | Hanke, Tomas | |
dc.contributor.author | John-Stewart, Grace | |
dc.date.accessioned | 2013-04-17T12:13:56Z | |
dc.date.available | 2013-04-17T12:13:56Z | |
dc.date.issued | 2005 | |
dc.identifier.citation | Vaccine. 2005 September 7; 23(38): 4711–4719. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/16043269 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16307 | |
dc.description | Full text | en |
dc.description.abstract | Recombinant modified vaccinia virus Ankara expressing HIV-1 antigens (MVA.HIVA) was used in ELISpot assays to monitor HIV-1-specific T cell responses in infants. Responses to MVA.HIVA and HIV-1 peptides were examined in 13 infected and 81 exposed uninfected infants in Nairobi, Kenya. Responses to MVA.HIVA (38%) and peptide stimulation (38%) were similar in frequency (p = 1.0) and magnitude (mean 176 versus 385 HIVSFU/106, p = 0.96) in HIV-1 infected infants. In exposed uninfected infants, MVA.HIVA detected more positive responses and higher magnitude responses as compared to peptide. MVA.HIVA ELISpot is a sensitive method for quantification of HIV-1-specific CD8+ T cell responses in HIV-1 exposed infants. These results demonstrate the relevance of HIV-1 clade A consensus-derived immunogen HIVA for the viruses currently circulating in Nairobi. | en |
dc.language.iso | en | en |
dc.subject | Exposed seronegatives | en |
dc.subject | HIV-1 | en |
dc.subject | Vaccinia Ankara | en |
dc.title | Modified vaccinia Ankara expressing HIVA antigen stimulates HIV-1-specific CD8 T cells in ELISpot assays of HIV-1 exposed infants[star] | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology | en |
local.publisher | Department of Paediatrics | en |