dc.contributor.author | Abinya, N.A.O. | |
dc.contributor.author | Nyabola, L.O. | |
dc.date.accessioned | 2013-04-17T12:20:00Z | |
dc.date.available | 2013-04-17T12:20:00Z | |
dc.date.issued | 2001 | |
dc.identifier.citation | East African Medical Journal | en |
dc.identifier.uri | http://cat.inist.fr/?aModele=afficheN&cpsidt=1129517 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16308 | |
dc.description.abstract | OBJECTIVES: To evaluate the frequency and severity of occurrence of vincristine-associated neurotoxicity. DESIGN: A retrospective case series study. SETTING: Hurlingham Oncology Clinic, Nairobi. SUBJECTS: Thirty-eight patients treated for various neoplasms with vincristine containing chemotherapeutic regimens. MAIN OUTCOME MEASURES: The frequency and degree of neurotoxicity when vincristine was given at the standard dose of 1.4 mg/m2. RESULTS: Five patients (13.2%) developed peripheral neuropathy, one having had it even before vincristine was started. Therefore only four (10.5%) had it attributed to vincristine. Four of the patients who developed neuropathy (80%) were HIV-positive. Neuropathy grade 2 (severe) occurred in only two patients leading to discontinuation of the drug. All the neurotoxicity resolved after discontinuation of vincristine. CONCLUSION: Vincristine induced neuropathy occurred but was rarely severe at a dose of 1.4 mg/m2. It appeared to be more frequent in HIV infected individuals, but controlled studies with bigger sample sizes are required to determine whether this may warrant routine capping of the dose at a maximum of 2 mg. | en |
dc.language.iso | en | en |
dc.relation.ispartofseries | Vol. 78, no7, pp. 376-378 (14 ref.) (2001); | |
dc.subject | Vincristine | en |
dc.subject | Toxicity | en |
dc.subject | Nervous system | en |
dc.subject | Antineoplastic agent | en |
dc.subject | Statistical study | en |
dc.title | Experience with vincristine-associated neurotoxicity | en |
dc.type | Article | en |
local.publisher | Department of Medicine. College of Health Sciences. University of Nairobi | en |