dc.contributor.author | Gitau, Wilfred | |
dc.contributor.author | Songoro, Edinah K | |
dc.contributor.author | Gathirwa, Jeremiah W | |
dc.contributor.author | Kimani, Francis | |
dc.contributor.author | Kariuki, Humphrey N | |
dc.date.accessioned | 2023-10-31T08:15:21Z | |
dc.date.available | 2023-10-31T08:15:21Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Wilfred G, Songoro EK, Gathirwa JW, Kimani F, Kariuki HN. In vivo antiplasmodial activities of stem bark extracts of Avicennia marina in Plasmodium berghei-infected mice. Pan Afr Med J. 2023 Feb 16;44:93. doi: 10.11604/pamj.2023.44.93.38448. PMID: 37229304; PMCID: PMC10204109. | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/37229304/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/163837 | |
dc.description.abstract | Introduction: malaria remains the leading cause of morbidity and mortality in developing tropical and subtropical nations. Due to the emergence and spread of drug resistance to currently available drugs, there is a need for the search of novel, safe, and reasonably affordable anti-malarial medications. The objective of this study was to assess the in vivoanti-malarial effectiveness of Avicennia marina stem bark extracts in a mice model.
Methods: guidelines 425 of the Organization for Economic Cooperation and Development were used to determine the extracts' acute toxicity. Mice infected with chloroquine-sensitive Plasmodium berghei (ANKA strain) were tested for in vivoanti-plasmodial activity, and by giving oral doses of 100 mg/kg, 250 mg/kg, and 500 mg/kg body weight of extracts, the plant's suppressive, curative, and preventive effects were assessed.
Results: mice treated with dosages of up to 5000 mg/kg showed no evidence of acute toxicity or mortality. Consequently, it was determined that the acute lethal dosage of Avicennia marina extracts in swiss albino mice was greater than 5000 mg/kg. All doses of the extracts exhibited significant (p<0.05) dose-dependent suppression of P. berghei in the suppressive tests compared to the control group. At the highest dose (500 mg/kg), Methanolic crude extracts exerted the highest (93%) parasitemia suppression during the 4-day suppressive test. The extracts also displayed significant (p<0.001) prophylactic and curative activities at all doses compared to the control.
Conclusion: results from this study ascertained the safety and promising curative, prophylactic and suppressive anti-plasmodial capabilities of the stem bark extracts of Avicennia marina in mice model. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Avicenia marina; Malaria; P. berghei; mice; suppression. | en_US |
dc.title | In vivo antiplasmodial activities of stem bark extracts of Avicennia marina in Plasmodium berghei-infected mice | en_US |
dc.type | Article | en_US |