dc.contributor.author | Akampurira, Denis | |
dc.contributor.author | Akala, Hoseah M | |
dc.contributor.author | Derese, Solomon | |
dc.contributor.author | Heydenreich, Matthias | |
dc.contributor.author | Yenesew, Abiy | |
dc.date.accessioned | 2023-11-16T05:53:44Z | |
dc.date.available | 2023-11-16T05:53:44Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Akampurira D, Akala HM, Derese S, Heydenreich M, Yenesew A. A new C-C linked benzophenathridine-2-quinoline dimer, and the antiplasmodial activity of alkaloids from Zanthoxylum holstzianum. Nat Prod Res. 2023 Jul;37(13):2161-2171. doi: 10.1080/14786419.2022.2034810. Epub 2022 Feb 9. PMID: 35139708. | en_US |
dc.identifier.uri | https://pubmed.ncbi.nlm.nih.gov/35139708/ | |
dc.identifier.uri | http://erepository.uonbi.ac.ke/handle/11295/163982 | |
dc.description.abstract | The CH2Cl2/MeOH (1:1) extract of Zanthoxylum holstzianum stem bark showed good antiplasmodial activity (IC50 2.5 ± 0.3 and 2.6 ± 0.3 µg/mL against the W2 and D6 strains of Plasmodium falciparum, respectively). From the extract five benzophenanthridine alkaloids [8-acetonyldihydrochelerythrine (1), nitidine (2), dihydrochelerythine (3), norchelerythrine (5), arnottianamide (8)]; a 2-quinolone alkaloid [N-methylflindersine (4)]; a lignan [4,4'-dihydroxy-3,3'-dimethoxylignan-9,9'-diyl diacetate (7)] and a dimer of a benzophenanthridine and 2-quinoline [holstzianoquinoline (6)] were isolated. The CH2Cl2/MeOH (1:1) extract of the root bark afforded 1, 3-6, 8, chelerythridimerine (9) and 9-demethyloxychelerythrine (10). Holstzianoquinoline (6) is new, and is the second dimer linked by a C-C bond of a benzophenanthridine and a 2-quinoline reported thus far. The compounds were identified based on spectroscopic evidence. Amongst five compounds (1-5) tested against two strains of P. falciparum, nitidine (IC50 0.11 ± 0.01 µg/mL against W2 and D6 strains) and norchelerythrine (IC50 value of 0.15 ± 0.01 µg/mL against D6 strain) were the most active. | en_US |
dc.language.iso | en | en_US |
dc.publisher | University of Nairobi | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.subject | Antiplasmodial; benzophenanthridine alkaloid; holstzianoquinoline; rutaceae; Zanthoxylum holstzianum. | en_US |
dc.title | A new C-C linked benzophenathridine-2-quinoline dimer, and the antiplasmodial activity of alkaloids from Zanthoxylum holstzianum | en_US |
dc.type | Article | en_US |