Adverse Maternal-perinatal Outcomes and Associated Risk Factors in Hellp Syndrome at Kenyatta National Hospital

Abstract

Background: HELLP syndrome complicates around 0.9% of all pregnant women and up to 20% of women with severe preeclampsia and eclampsia. HELLP Syndrome has been significantly associated with adverse maternal-perinatal outcomes. Adverse maternal outcomes associated with HELLP include maternal death as well as severe morbidity such as placental abruption, renal failure, and intensive care unit admissions. The associated perinatal adverse include jaundice, respiratory distress syndrome, neonatal intensive care admissions, small for gestational age, and perinatal death. However, factors associated with these adverse outcomes have not been exhaustively investigated particularly in the local context. Objectives: To determine adverse maternal-perinatal outcomes associated factors in patients with HELLP syndrome at Kenyatta National Hospital (KNH) from 1st January 2016 to December 31st, 2020. Methodology: This will be an analytical cross-sectional study conducted at KNH. A systematic sampling technique will be used to enroll 385 patients diagnosed with HELLP Syndrome from 1st January 2016 to 31st December 2020. A data abstraction tool will be used to collect data from patient files. Data extracted will include patient demographic characteristics, clinical presentation, biological factors as well as maternal and perinatal adverse outcomes. The collected data will be entered in Epi-data version 3.1 and exported to Statistical Package for Social Sciences (SPSS version 26)...