Elevation of Heterophilic antibodies to rabbit erythrocytes in human pathologic sera: quantitative studies by Elisa using a Glycosphingolipid antigen
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Date
1987Author
Suzuki, E
Mukuria, J C
Naiki, M
Kurosawa, T
Hanaue, J
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
Human heterophilic hemagglutinin to rabbit erythrocytes was quantitatively
determined by the hemagglutination test and enzyme linked immunosorbent assay
(ELISA) using rabbit erythrocyte pentaglycosyl ceramide (CPH), Gal (a 1-3) Gal
(fl 1-4) GlcNAc (fl 1-3) Gal (fl 1-4) Glc-Cer as the antigen. The antibody
levels in sera from 74 Hanganutziu-Deicher (H-D) antibody-positive patients were
significantly higher than those in sera from 55 healthy donors, and the correlation
between the antibody levels detected by ELISA and hemagglutinin titers was
significant. The antibody levels detected by ELISA correlated to the IgG antibody
levels, while the hemagglutinin titers correlated to the IgM antibody levels.
These results suggested that IgG levels as well as IgM levels against rabbit
erythrocytes were elevated in H-D antibody-positive patients with various tumors
and infectious diseases. In 4 out of 67 cancer patients collected randomly,
abnormally high levels of anti-CPR IgG antibody were detected.
URI
http://eprints.lib.hokudai.ac.jp/dspace/bitstream/2115/3027/1/KJ00002374451.pdfhttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16530
Citation
Japan Journal of Veterinary Research, 35, 11-20 (1987)Publisher
College of Health Sciences, University of Nairobi
Subject
Heterophile antigenHeterophile antibody
Natural antibody
Glycosphingolipid
Rabbit erythrocyte
Description
Journal article
Collections
- Faculty of Health Sciences (FHS) [10378]