dc.contributor.author | Martin, HL | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | Nyange, PM | |
dc.contributor.author | Lavreys, L | |
dc.contributor.author | Hillier, SL | |
dc.contributor.author | Chohan, B | |
dc.contributor.author | Mandaliya, K | |
dc.contributor.author | Ndinya-Achola Jeckoniah O. | |
dc.contributor.author | Bwayo, JJ | |
dc.contributor.author | Kreiss, J | |
dc.date.accessioned | 2013-04-25T11:43:29Z | |
dc.date.available | 2013-04-25T11:43:29Z | |
dc.date.issued | 1999 | |
dc.identifier.citation | J Infect Dis. 1999 Dec;180(6):1863-8. | en |
dc.identifier.uri | www.ncbi.nlm.nih.gov/whalecom0/pubmed/10558942 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/16785 | |
dc.description.abstract | A prospective cohort study was conducted to examine the relationship between vaginal colonization with lactobacilli, bacterial vaginosis (BV), and acquisition of human immunodeficiency virus type 1 (HIV-1) and sexually transmitted diseases in a population of sex workers in Mombasa, Kenya. In total, 657 HIV-1-seronegative women were enrolled and followed at monthly intervals. At baseline, only 26% of women were colonized with Lactobacillus species. During follow-up, absence of vaginal lactobacilli on culture was associated with an increased risk of acquiring HIV-1 infection (hazard ratio [HR], 2.0; 95% confidence interval [CI], 1.2-3.5) and gonorrhea (HR, 1.7; 95% CI, 1.1-2.6), after controlling for other identified risk factors in separate multivariate models. Presence of abnormal vaginal flora on Gram's stain was associated with increased risk of both HIV-1 acquisition (HR, 1.9; 95% CI, 1.1-3.1) and Trichomonas infection (HR, 1.8; 95% CI, 1.3-2.4). Treatment of BV and promotion of vaginal colonization with lactobacilli should be evaluated as potential interventions to reduce a woman's risk of acquiring HIV-1, gonorrhea, and trichomoniasis | en |
dc.language.iso | en | en |
dc.title | Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |
local.publisher | Department of Medicine, University of Washington, Seattle, USA | en |