Cofactors in male-female sexual transmission of human immunodeficiency virus type 1
View/ Open
Date
1991Author
Plummer, FA
Simonsen, JN
Cameron, DW
Ndinya-Achola, JO
Kreiss, JK
Gakinya, MN
Waiyaki, P
Cheang, M
Piot, P
Ronald, AR
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
In a study of human immunodeficiency virus type 1 (HIV-1)-uninfected African prostitutes, 83 (67%) of 124 seroconverted to HIV-1. Oral contraceptive use (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.1-8.6; P less than .03), genital ulcers (mean annual episodes, 1.32 +/- 0.55 in seroconverting women vs. 0.48 +/- 0.21 in seronegative women; P less than .02) and Chlamydia trachomatis infections (OR, 3.6; CI, 1.3-11.0; P less than .02) were associated with increased risk of HIV-1 infection. Condom use reduced the risk of HIV-1 infection (OR, 0.11; CI, 0.05-0.27; P less than .0001). Stepwise logistic regression analysis confirmed independent associations between HIV-1 infection and oral contraceptive use, condom use, genital ulcers, and C. trachomatis. The presence of other sexually transmitted diseases may in part explain the heterosexual HIV-1 epidemic in Africa and may represent important targets for intervention to control HIV-1 infection
URI
http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/1988508http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17036
Citation
J Infect Dis. 1991 Feb;163(2):233-9Publisher
Kenya Medical Research Institute Department of Medical Microbiology, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10387]