dc.contributor.author | Laga, M | |
dc.contributor.author | Naamara, W | |
dc.contributor.author | Brunham, RC | |
dc.contributor.author | D'Costa, LJ | |
dc.contributor.author | Nsanze, H | |
dc.contributor.author | Piot, P | |
dc.contributor.author | Kunimoto, D | |
dc.contributor.author | Ndinya-Achola Jeckoniah O. | |
dc.contributor.author | Slaney, L | |
dc.contributor.author | Ronald, AR | |
dc.date.accessioned | 2013-04-26T12:32:50Z | |
dc.date.available | 2013-04-26T12:32:50Z | |
dc.date.issued | 1986 | |
dc.identifier.citation | N Engl J Med. 1986 Nov 27;315(22):1382-5 | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/3095641 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17146 | |
dc.description.abstract | We conducted a randomized clinical trial comparing a single intramuscular dose of 125 mg of ceftriaxone with a single intramuscular dose of 75 mg of kanamycin followed by topical gentamicin for seven days, and with a single intramuscular dose of 75 mg of kanamycin followed by topical tetracycline for seven days, in the treatment of gonococcal ophthalmia neonatorum in Nairobi, Kenya. Of 122 newborns with culture-proved gonococcal ophthalmia neonatorum, 105 returned for follow-up. Sixty-one infants (54 percent) received ceftriaxone, 32 received kanamycin plus topical gentamicin, and 29 received kanamycin plus topical tetracycline. Sixty-six (54 percent) of the Neisseria gonorrhoeae isolates were penicillinase producing. All 55 newborns who received ceftriaxone and returned for follow-up were clinically and microbiologically cured. One of 26 returning newborns who received kanamycin plus tetracycline and 2 of 24 returning newborns who received kanamycin plus gentamicin had persistent or recurrent gonococcal conjunctivitis. Ceftriaxone also eradicated oropharyngeal gonococcal infection in 18 newborns, whereas oropharyngeal infection persisted in 2 of 8 newborns who had received kanamycin (P not significant). We conclude that 125 mg of ceftriaxone as a single intramuscular dose is very effective therapy for gonococcal ophthalmia neonatorum, with marked efficacy against extraocular infection and without the need for concomitant topical antimicrobial therapy. | en |
dc.language.iso | en | en |
dc.title | Single-dose therapy of gonococcal ophthalmia neonatorum with ceftriaxone | en |
dc.type | Article | en |
local.publisher | Department of Medical Microbiology, University of Nairobi | en |