Pyrenes and pyrendiones from Uvaria lucida.
dc.contributor.author | Moriyasu, M, | |
dc.contributor.author | Takeuchi, S | |
dc.contributor.author | Ichimaru, M, | |
dc.contributor.author | Nakatani, N, | |
dc.contributor.author | Nishiyama, Y, | |
dc.contributor.author | Kato, A, | |
dc.contributor.author | Mathenge, S.G | |
dc.contributor.author | Juma, F.D | |
dc.contributor.author | ChaloMutiso, P.B | |
dc.date.accessioned | 2013-04-27T10:43:46Z | |
dc.date.available | 2013-04-27T10:43:46Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | J Nat Med. 2012 Jul;66(3):453-8 | en |
dc.identifier.uri | http://hinari-gw.who.int/whalecomwww.ncbi.nlm.nih.gov/whalecom0/pubmed/22127529 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/17371 | |
dc.description.abstract | A chemical investigation of the chloroform extract of the roots of Uvaria ludida Benth. (Annonaceae), an important African traditional medicine, led to the isolation of six new compounds; three pyrenes, 2-hydroxy-1,8-dimethoxypyrene (1), 8-methoxy-1,2-methylenedioxypyrene (2), and 7-hydroxy-8-methoxy-1,2-methylenedioxypyrene (3), two pyrenediones, 2-hydroxy-1,8-pyrenedione (4) and 2-methoxy-1,8-pyrenedione (5), and a sesquiterpene, (-)-10-oxo-isodauc-3-en-15-oic acid (6), together with eight known compounds (7-14). The structural elucidation by spectroscopic studies of the compounds isolated is described. While pyrenes did not exhibit strong cytotoxicity against human promyelocytic leukemia HL-60 cells, pyrenediones showed strong cytotoxicity. The IC(50) of 4 was 70 ng mL(-1), which was close to that of etoposide (IC(50) = 60 ng mL(-1)). | en |
dc.language.iso | en | en |
dc.title | Pyrenes and pyrendiones from Uvaria lucida. | en |
dc.type | Article | en |
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