dc.contributor.author | Rono, BC | |
dc.date.accessioned | 2013-05-06T08:23:46Z | |
dc.date.available | 2013-05-06T08:23:46Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Master of Science in Veterinary Epidemiology and Economics | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/19294 | |
dc.description.abstract | Contagious bovine pleuropneumonia (CBPP) is a disease of major economic
importance in many countries in sub Saharan Africa. Routine vaccination
remains the preferred option for control of the disease. The purpose of the
present study was to evaluate the effect of two live attenuated TA4 Mycoplasma
mycoides mycoides small colony (MmmSC) vaccines: a modified vaccine
cultured in a buffered growth media and a conventional vaccine cultured in
unbuffered media on the prevalence of CBPP in cattle in the Maasai ecosystem.
The study population consisted of cattle under pastoral production system in
Loita, Mara and Osupuko divisions of the greater Narok District.
Approximately eighty thousand (80, 000) cattle in 458 participating herds were
randomly allocated such that half received either the conventional vaccine or
modified vaccine in February/ March 2007. Data including age, sex and
geographical location were recorded in a data base. An abattoir study was
conducted 9 to 15 months post vaccination in 4 slaughterhouses in Dagoretti to
compare prevalence of lung lesions suggestive of CBPP and MmmSC antibodies
in a randomly selected sample of the two study groups.
Thorough examination of 424 lungs from cattle vaccinated with either the
conventional (227) or modified (197) vaccines did not reveal any lesions suggestive
XVI
of CBPP. Antibody prevalence was investigated by complement fixation test (CFT)
and competitive enzyme linked immunosorbent assay (cELlSA). The
seroprevalence estimated by cELlSA were 17% and 11.3% in the conventional and
modified groups respectively while CFT estimates were 6.3% and 1.3%. However,
a statistically significant association between vaccine type and antibody prevalence
was only demonstrated by CFT (P = 0.024). Univariate logistic regression analysis
showed that period post vaccination (P = 0.058), division (P = 0.009) and vaccine
type (P = 0.076) were significantly associated with presence of MmmSC.
This study did not find convincing evidence to show any difference in the
protection provided by conventional and modified vaccines 9 to 15 months
following vaccination. Both vaccines could be equally effective in preventing
development of disease. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Comparison of effects of two contagious Bovine Pleuropneumonia vaccines on Lung lesions and Seroprev Alence in Cattle kept under the Maasai ecosystem | en |
dc.type | Thesis | en |
local.publisher | Department of Public Health, Pharmacology and Toxicology, University of Nairobi, Kenya | en |