dc.contributor.author | Mackelprang, Romel D | |
dc.contributor.author | Carrington, Mary | |
dc.contributor.author | John-Stewart, Grace | |
dc.contributor.author | Lohman-Payne, Barbara | |
dc.contributor.author | Richardson, Barbra A | |
dc.contributor.author | Wamalwa, Dalton | |
dc.contributor.author | Gao, Xiaojiang | |
dc.contributor.author | Majiwa, Maxwel | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | Farquhar, Carey | |
dc.date.accessioned | 2013-05-08T14:42:30Z | |
dc.date.available | 2013-05-08T14:42:30Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | J Infect Dis. 2010 October 15; 202(8): 1273–1277. | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/20405 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/20812845 | |
dc.description | Full text | en |
dc.description.abstract | We examined associations between maternal HLA and vertical HIV-1 transmission in a perinatal cohort of 277 HIV-infected women in Nairobi. HLA class I genes were amplified using sequence-specific oligonucleotide probes and analyses were performed using logistic regression. Maternal A*2301 was associated with increased transmission risk before and after adjusting for maternal viral load (odds ratio [OR]=3.21; 95% CI: 1.42, 7.27, p=0.005, pcorr=0.04; adjusted OR=3.07; 95% CI: 1.26, 7.51, p=0.01, pcorr=NS). That maternal HLA-A*2301 was associated with transmission independent of plasma HIV-1 RNA levels, suggests that HLA may alter infectivity through mechanisms other than influencing HIV-1 viral load. | en |
dc.language.iso | en | en |
dc.subject | HIV-1 transmission | en |
dc.subject | HIV-1 | en |
dc.subject | Human leukocyte antigen | en |
dc.title | Maternal Human Leukocyte Antigen - A*2301 Is Associated with Increased Mother-to-Child HIV-1 Transmission | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics | en |