Terpurinflavone: An antiplasmodial flavone from the stem of Tephrosia Purpurea
View/ Open
Date
2011Author
Heydenreich, Matthias
Muiva, Lois M.
Eyase, Fredrick L.
Akala, Hoseah M.
Wanyama, P. Juma
Yenesew, Abiy
Imbuga, Mabel
Walsh, Douglas S.
Peter, Martin G.
Gitu, Peter M.
Okalebo, Faith A.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
The stem extract of Tephrosia purpurea showed anti plasmodial activity against the D6 (chloroquinesensitive)
and W2 (chloroquine-resistant) strains of Plasmodium /aldparum with 1(50 values of
10.47 ± 2.22 f.Lg/mland 12.06 ± 2.54 f.Lg/ml,respectively. Anew prenylated flavone, named terpurinflavone,
along with the known compounds lanceolatin A.(-)-semiglabrin and lanceolatin Bhave been isolated from
this extract. The new compound, terpurinflavone, showed the highest anti plasmodial activity with 1(50
values of 3.12 ± 0.28 f.LM(D6) and 6.26 ± 2.66 f.LM(W2). The structures were determined on the basis of
spectroscopic evidence.
Local Identifier
doi:l0.1016/j.phytoI.2011.02.010Citation
Phytochemical Society of EuropePublisher
Elsevier B.V. Department of Chemistry,University of Nairobi United Stares Army Medical Research Unit-Kenya Department of Biochemistry, Jomo Kenyatta University of Agriculeure and Technology Insrieur fur Chemie, Universitat Potsdam, School of Pharmacy, University of Nairobi,
Description
Terpurinflavone: An antiplasmodial flavone from the stem of Tephrosia Purpurea