| dc.description.abstract | A panel of tests was selected and evaluated for the diagnosis of
di s s e rrrin at.ed intravascular coagulation (DIC). The cr;iteria used in
the selection of these tests was that they collectively rnu at be
accurate, rapid and relatively s irnp le to p e r fo r m . In addition, the
te sts were selected to fulfill the following objective s:
1) To provide he mato log ic al data considered irnpo rt ant
in helping to arrive at a tentative diagnosis of DIC.
2) To detect defects in the no rm al rrie c harri s rn of coagula,tion
and fibrinolysis.
The tests selected were designated as the Stat. DIC panel and
included the co rnpl et e blood count, the platelet count, the blood urea
nitrogen, the p r oth r ornb i.n t irn e, the activated partial throITl~oplastin
t irrie , the t hr omb in t irn e and fibrinogen degradation product deterrrrin
at ion ,
The plan was to evaluate this panel of tests bo th in experirnerrtal
ly produced DIC in dogs and in an irria l s with undiagnosed
bleeding p r obIe m s pre sented to Colorado State Univer sity Veterinary
Hospital.
Two methods were used in attempting to expe r irnerrtal.Ly produce
DIC. One method was the use of two intravenous injections of
Escherichia coli endotoxin in 10 dogs and the other method was
sur face -induced, deep hypothermia in 3 dogs. Neither method produced
clinical evidence of DIC and in only one of the 13 dogs was the
Stat. panel of tests positive for DIC.
Approximately 20 dogs presented to the Colorado State University
Veterinary Hospital were examined using the Stat. DIC panel
of te st s , Of the se, 5 showed po sitive evidence for DIC and we re
studied in detail. The primary disease in each of the se case s was
different and included obstetrical complications, a ruptured ab sce ss,
osteogenic sarcoma, chronic renal disease and sur gi cal shock. The se
case s pre sented a limited opportunity to evaluate chemotherapy | en |
