dc.contributor.author | Kariuki, Hellen N | |
dc.date.accessioned | 2013-05-20T15:58:30Z | |
dc.date.available | 2013-05-20T15:58:30Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | M.Sc (Medical Physiology) | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/23985 | |
dc.description | Master of Science Thesis | en |
dc.description.abstract | The aim of the present study was to investigate the analgesic
effects of clomipramine (a tricyclic antidepressant) and carbamazepine
(an anticonvulsant) individually, and in combination with pethidine (a
narcotic) in the formalin test.
Several doses of each drug were used in the experiment. The
lowest dose that caused significant change in the late phase of
formalin test was used in combination with pethidine. The pethidine
dose used in the combination experiments had no significant change
in the late phase of formalin test. The formalin test was performed by
injecting a dilute solution (20 jJl of 1% formalin in 0.9% NaCI)
subcutaneously in the right hind paw of both the controls and the test
animals. The time in seconds) spent in licking and, or lifting the paw
was monitored in blocks of 5 minutes for 1 hour. The drugs or
vehicle were injected 30 minutes prior to the formalin test. The drugs
were administered intraperitoneally. | en |
dc.description.sponsorship | University of Nairobi | en |
dc.language.iso | en | en |
dc.title | The analgesic effects of Clomipramine and Carbamazepine individually, and in combination with pethidine using the formalin test | en |
dc.type | Thesis | en |
local.publisher | Faculty of Science, University of Nairobi | en |