Modelling the factors influencing willingness to participate in hiv-l vaccine and microbicide trial: a case studyof Mathare perinatal city council clinic
Abstract
The study evaluates the suitability of women participating In perinatal HIV-l prevention
program for HIV-l vaccine and microbicide trials, willingness to participate in trials and knowledge
of current performance of vaccines in in general and the future HIV vaccine performance. Followup
among HIV-l uninfected women after delivery was done for a a period of upto 1 year.
Using participants in perinatal HIV-l prevention trials for vaccine and microbicide studies
possed several advantages as it provides an adquate infrastructure and easy follow-up, its a
high-risk cohort (group) and that women participating in Prevention of Mother- To-Child Transmission
programs are more representative of reproductive birth giving cohort with a higher risk
of infection.
The study entails finding a suitable odered logistic regression model which relates willingness
to the factors influencing it and responses on willingness were utilized in predicting a sub-set
of participants likely to be involved in the uptake and the subsequent participation of vaccinejmicrobicides
vaccine.
At enrollment a total of 797 participants were interviewed and their willingness to participate
was assessed through a face-to-face questionnaire and a follow-up for upto 1 year done. There
was consistently high knowledge on the ~IV prevention methods among the study participants.
However, knowledge on vaccines in general and on future HIV vaccines was relatively low. Willingness
to participate in the HIV vaccines was very high (> 80%) of the study participants citing
willingness to participant in HIV vaccine trials over the follow-up period.
On running an Ordered regr~s~ion model, effectiveness and side-effects of the current vaccines
were significant in modelling willingness to participate in the vaccine trials. The performance of
the current vaccines is still key to future vaccine develoQme~s and their side-effects need to be
minimized for better results and enhanced participation in future vaccine trials.
Citation
M.Sc (Biometry)Sponsorhip
University of NairobiPublisher
School of Mathematics, University of Nairobi
Description
Master of Science Thesis