dc.contributor.author | Wambua, Alex M | |
dc.date.accessioned | 2013-05-22T06:30:52Z | |
dc.date.available | 2013-05-22T06:30:52Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | M.Sc (Biometry) | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/24295 | |
dc.description | Master of Science Thesis | en |
dc.description.abstract | The study evaluates the suitability of women participating In perinatal HIV-l prevention
program for HIV-l vaccine and microbicide trials, willingness to participate in trials and knowledge
of current performance of vaccines in in general and the future HIV vaccine performance. Followup
among HIV-l uninfected women after delivery was done for a a period of upto 1 year.
Using participants in perinatal HIV-l prevention trials for vaccine and microbicide studies
possed several advantages as it provides an adquate infrastructure and easy follow-up, its a
high-risk cohort (group) and that women participating in Prevention of Mother- To-Child Transmission
programs are more representative of reproductive birth giving cohort with a higher risk
of infection.
The study entails finding a suitable odered logistic regression model which relates willingness
to the factors influencing it and responses on willingness were utilized in predicting a sub-set
of participants likely to be involved in the uptake and the subsequent participation of vaccinejmicrobicides
vaccine.
At enrollment a total of 797 participants were interviewed and their willingness to participate
was assessed through a face-to-face questionnaire and a follow-up for upto 1 year done. There
was consistently high knowledge on the ~IV prevention methods among the study participants.
However, knowledge on vaccines in general and on future HIV vaccines was relatively low. Willingness
to participate in the HIV vaccines was very high (> 80%) of the study participants citing
willingness to participant in HIV vaccine trials over the follow-up period.
On running an Ordered regr~s~ion model, effectiveness and side-effects of the current vaccines
were significant in modelling willingness to participate in the vaccine trials. The performance of
the current vaccines is still key to future vaccine develoQme~s and their side-effects need to be
minimized for better results and enhanced participation in future vaccine trials. | en |
dc.description.sponsorship | University of Nairobi | en |
dc.language.iso | en | en |
dc.title | Modelling the factors influencing willingness to participate in hiv-l vaccine and microbicide trial: a case studyof Mathare perinatal city council clinic | en |
dc.type | Thesis | en |
local.publisher | School of Mathematics, University of Nairobi | en |