dc.contributor.author | Mpekethu, Mingaine | |
dc.date.accessioned | 2013-05-23T07:22:08Z | |
dc.date.available | 2013-05-23T07:22:08Z | |
dc.date.issued | 2009 | |
dc.identifier.citation | Master of Medicine in Ophthalmology | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/24632 | |
dc.description.abstract | Objective: To determine the magnitude and pattern of intraocular pressure (JOP)
changesin eyes that received intravitreal triamcinolone acetonide in Kikuyu Eye
Unit.
Study Design: retrospective interventional case series.
Setting: Kikuyu Eye Unit.
Subjects: Seventy-two eyes (of 61 patients) injected between January 2007 and
August2008.
Methods: Data on lOP, indication for injection, additional procedures (cataract
surgery,retinal photocoagulation), and treatment was collected using
questionnairesand analysed using SPSS version 11.5.
Results: The mean pre-injection lOP was 16.0 (SD 5.2) mmllg, which increased to
23.8 (SD 11.5) mmHg after intravitreal triamcinolone acetonide injection
(p<O.OOI). lOP started increasing significantly within 2 weeks (p=0.006). The
medianpost-injection time before lOP peak was 4.6 weeks, and lOP remained high
for 24 weeks after injection. Intraocular pressure increase of 5 mmHg or more was
foundin 39 (54.2%) eyes, while that of 10 mmlIg or more was found in 22
(30.1%).Increase of more than a third of pre-injection lOP was noted in 41 (56.9%)
eyes.Thirty-three eyes (45.80/0)had maximum post-injection lOP beyond 21
nunllg. Twenty-two eyes (30.6%) received treatment for lOP elevation - mostly
antiglaucomamedication - and one required cyclophotocoagulation. Eyes with
pre-injectionrop of more than 21 mml-lg were associated with significantly higher
lOP increases (p<O.OOI)and all received pressure-lowering medication. No
associations were noticed between age, sex, other procedures, diagnosis and
pattern ofIOP change.
Conclusions: Intraocular increase was found to be a common complication of
intravitreal triamcinolone acetonide, and the increase occurred mostly in the first
8
six months. Almost a third of eyes on treatment with lntravitreal triamcinolone
acetonide received intervention for increased lOP.
Recommendations: Close follow-up of eyes receiving lVTA is needed, and eyes
with lOP over 21 mmlIg may benefit from prophylactic antiglaucoma medication
immediately after lYTA. | en |
dc.language.iso | en | en |
dc.publisher | University Of Nairobi | en |
dc.title | Intraocular Pressure Changes in Eyes Receiving Intravitreal Triamcinolone Acetonide in Kikuyu Eye Unit | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | College of Health Sciences | en |