dc.contributor.author | Ndege, PK | |
dc.date.accessioned | 2013-05-23T11:45:45Z | |
dc.date.available | 2013-05-23T11:45:45Z | |
dc.date.issued | 2002 | |
dc.identifier.citation | Master Of Medicine (internal Medicine) Of The University Of Nairobi, 2002 | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/24845 | |
dc.description.abstract | Objective: The aim of the study was to determine the prevalence of alpha-fetoprotein levels,
HBsAg, IgGanti-HBc, anti-HCV and HIV antibodies among patients with primary
hepatocellular carcinoma at KNH.
Study design & setting: The study design was a cross-sectional descriptive survey, done at
the Kenyatta National Hospital, Nairobi, Kenya.
Methods: Patients with a histological diagnosis of primary hepatocellular carcinoma were
recruited. History was obtained, physical examination done, and blood taken for
determination of alpha-fetoprotein level, hepatitis B, C and HIV seropositivity.
Results: 62 patients were studied, 39 males and 23 females, with an age range of 21 to 79
years and a mean of 49.7 years (median 50.0,SD 13.4). The prevalence of various viral
markers was as follows: HBsAg 56.5%, IgG Anti-HBc 57.9%, HIV 17.7% and Anti-HCV 9.7%.
43.5% had associated liver cirrhosis. HCV positivity was significantly associated with
cirrhosis (p= .039). HBsAg and anti-HBc positivity were significantly associated with higher
AFP levels (p= .0008). Higher AFP levels were also significantly associated with age below
50 years (p= .021).
Conclusions: The prevalence of hepatitis B virus markers among PHC patients was (71%).
All patients that had positive alpha-fetoprotein levels were positive for hepatitis B markers,
and in this same group of patients, age played a role in that those below 50 years had higher
levels. Hepatitis C accounted for 9.7% of patients with primary hepatocellular carcinoma.
17.7% of patients with primary hepatocellular carcinoma were positive for HIV (ELISA I &
This figure was slightly lower than that expected for KNH in-patients (20%) but significantly
higher than that of the general population (12%). 43.5% of the patients with primary
hepatocellular carcinoma had associated liver cirrhosis. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | The Prevalence Of Hepatitis B, C And, Hiv Markers And α-fetoprotein Levels In Patients With Primary Hepatocellular Carcinoma At Kenyatta National Hospital | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | Faculty of Medicine | en |