dc.contributor.author | Mbogo, David M | |
dc.date.accessioned | 2013-05-24T10:00:39Z | |
dc.date.available | 2013-05-24T10:00:39Z | |
dc.date.issued | 2010 | |
dc.identifier.citation | Masters of Medicine | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/25360 | |
dc.description.abstract | Migraine is a common disorder characterized by recurrent disabling attacks of
headache associated with nausea, vomiting, and hypersensitivity to light, sound,
and smell and in a third of patients, neurological aura symptoms usually consisting
of visual disturbance. Significant genetic mechanisms underlie its aetiology.
Homozygous C677T mutation in the MTHFR gene is a genetic risk factor for
migraine. These homozygotes have elevated blood homocysteine levels.
The purpose of this study was to measure serum homocysteine as a marker of
C677T mutation in the MTHFR gene in patients with migraine as compared with
controls in our setup.
The study was a cross-sectional descriptive survey.
Kenyatta National Hospital adult neurology clinic, medical outpatient clinics,
medical wards and the accident and emergency department
All patients in the above departments with headache consistent with migraine in
accordance with the international headache society diagnostic criteria and who fit
the other eligibility criteria were included in the study. We studied 50 migraine
patients aged between 18 to 58 years. The mean age was 33.5 and a median of32.0
(27.0-40.0). The mode was 40. The males were 320/0and the females were 680/0.
All patients with headache were interviewed and examined. Those who met the
international headache society diagnostic criteria for migraine and consented to the
study were guided by the investigator to fill a study questionnaire. Homocysteine
assay was then performed on each of the cases. Control group was picked from
patients' non related escorts and from gynaecological and surgical outpatient
clinics. They were matched for age to the nearest year and for gender.
The Statistical Package for Social Sciences version 14.2 software for windows was
used to analyze the data.
A total of 50 patients were recruited in the study. 580/0had migraine with aura,
38%had migraine without aura and 40/0had catamenial form of migraine variant.
Onepatient had a seizure complication.
When we did homocysteine assay we found no difference between the cases and
the controls. The mean homocysteine in test subjects was 21.8~mol/1 and in the
controls was 21.1~mol with a p-value of 0.770. The median in test subjects was
2l.1 (13.9-28.8) whereas in controls it was 20.7 (12.8-27.6).
There is no association between migraine and hyperhomocysteinemia and by
extension the C677T gene mutation in our setup. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | Serum Homocysteine In Patients With Migraine Headache At Kenyatta National Hospital. | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | School of Medicine | en |