dc.contributor.author | Nyawanda, Henry | |
dc.date.accessioned | 2013-05-25T10:30:15Z | |
dc.date.available | 2013-05-25T10:30:15Z | |
dc.date.issued | 2007 | |
dc.identifier.citation | Degree Of Master Of Medicine in General Surgery of the University Of Nairobi | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/11295/25677 | |
dc.description | Dissertation submitted in partial
fulfilment of requirements for the
award of the Degree Of Master Of
Medicine in General Surgery of the
University Of Nairobi | en |
dc.description.abstract | Objective:to investigate and determine the relationship between anti-EBV
ImmunoglobulinA titre levels and nasopharyngeal carcinoma and its significance in
patients diagnosed at Kenyatta National Hospital
Design:case control study
Setting:the study was conducted in the ENT, pathology, and radio-oncology departments
ofuniversityof Nairobi and KNH.
Methodology:5 mls of venous blood was collected from 80 patients with a histological
diagnosisof NPC, and 80 randomly selected blood donors at the blood transfusion unit.
Serumcollected was subjected to an ELISA test to determine the titre levels of EBV
specificIgA antibodies, levels of EBV titres in the patients with NPC were compared
withthose of the control group.
Results:show that 35% of patients with NPC had raised titres (titre level> 1:10) while
22.5%, of the control group had raised titres , correlating well with other international
studies done elsewhere.
Conclusions: anti-EBV IgA titre levels are significantly raised in patients with
nasopharyngeal carcinoma and is not sensitive enough to be used as a diagnostic
test.however the titres can be used as an aid in diagnosis in cases where histological
diagnosis is unclear, but clinical evidence points in direction of nasopharyngeal
carcmoma. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi | en |
dc.title | EBV
VCA
specific
immunoglobulin
a
serum
antibody
titre
levels
in
nasopharyngeal
carcinoma
patients
at
the
Kenyatta
National
Hospital | en |
dc.type | Thesis | en |
dc.description.department | a
Department of Psychiatry, University of Nairobi, ; bDepartment of Mental Health, School of Medicine,
Moi University, Eldoret, Kenya | |
local.publisher | Department of surgery | en |