dc.contributor.author | De Souza, M S | |
dc.date.accessioned | 2013-05-29T07:12:56Z | |
dc.date.available | 2013-05-29T07:12:56Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | M.Sc (Biochemistry) | en |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/26787 | |
dc.description | Master of Science Thesis | en |
dc.description.abstract | The efficacy of the few available trypanocides is being seriously compromised
by the emergence and spread of drug resistant trypanosome strains. Elucidation
of the molecular genetic basis of this phenotype may contribute to an
understanding of the mechanisms of development of resistance to the
trypanocides. This knowledge can be exploited for the rational design of drugs
to which the parasites may not easily develop resistance.
In order to investigate genetic mechanisms underlying the isometamidium
chloride resistance in African trypanosomes, a clone of Trypanosoma
congolense was made 200-fold more resistant to the drug by continued
subcurative treatment. Comparative differential display analysis was carried
out on cDNA prepared from the isometamidium sensitive trypanosome clone,
IL 1180, and its resistant derivative, IL1180x200R. | en |
dc.description.sponsorship | University of Nairobi | en |
dc.language.iso | en | en |
dc.title | Analysis of two putative candidate genes for Isometamidium resistance in Trypanosoma congolense | en |
dc.type | Thesis | en |
local.publisher | Department of Biochemistry, University of Nairobi | en |