Oxamniquine inhibits metabolism of caffeine, hexobarbitone and antipyrine in vivo in mice
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Date
1996-08Author
Kokwaro, GO
Indalo, Anne A
Type
ArticleLanguage
enMetadata
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Inhibition of hepatic metabolism of caffeine (as assessed from expiration of (14)CO(2) resulting from N-demethylation of (14)C-labelled caffeine), hexobarbitone (as assessed from sleeping times) and antipyrine (as assessed from expiration of I4CO2 resulting from the oxidation of "C-labelled antipyrine) was studied in male GB-1 mice administered a single SO mg kg-1 oral dose of the schistosomicidal drug oxamniquine. Metabolism of caffeine, catalysed by cytochrome P-4S0 1A2(CYP1A2), was inhibited most, while hexobarbitone and antipyrine metabolism were inhibited to a lesser, though significant, degree. These results indicate a need for further studies to investigate possible clinically relevant inhibition of hepatic drug metabolism by oxamniquine
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http://profiles.uonbi.ac.ke/aindalo/publications/kokwaro-go-indalo-aaoxamniquine-inhibits-metabolism-caffeine-hexobarbitone-and-http://www.ncbi.nlm.nih.gov/pubmed/17451311
http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/28319
Citation
Afr J Health Sci. 1996 Aug;3(3):105-8.Publisher
University of Nairobi. Department of Pharmaceutics and Pharmacy Practice, Faculty of Pharmacy, University of Nairobi
Collections
- Faculty of Health Sciences (FHS) [10378]