Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk
dc.contributor.author | Farquhar, C | |
dc.contributor.author | VanCott, TC | |
dc.contributor.author | Mbori-Ngacha, DA | |
dc.contributor.author | Horani, L | |
dc.contributor.author | Bosire, RK | |
dc.contributor.author | Kreiss, JK | |
dc.contributor.author | Richardson, BA | |
dc.contributor.author | John-Stewart, GC | |
dc.date.accessioned | 2013-06-10T06:44:43Z | |
dc.date.available | 2013-06-10T06:44:43Z | |
dc.date.issued | 2002-10 | |
dc.identifier.citation | J Infect Dis. 2002 Oct 15;186(8):1173-6. Epub 2002 Sep 20. | en |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/18505437 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30384 | |
dc.description.abstract | Secretory leukocyte protease inhibitor (SLPI), a protein found in saliva, breast milk, and genital secretions, is capable of inhibiting human immunodeficiency virus (HIV) type 1 in vitro. The aim of this study was to determine whether SLPI in infant saliva provides protection against mother-to-child HIV-1 transmission. In total, 602 saliva specimens were collected from 188 infants at birth and at ages 1, 3, and 6 months. Infants' median salivary SLPI concentrations were higher at birth than at 6 months (341 vs. 219 ng/mL; P=.001). There was no association between SLPI concentration and HIV-1 transmission overall. However, among 122 breast-fed infants who were HIV-1 uninfected at 1 month, higher salivary SLPI levels were associated with a decreased risk of HIV-1 transmission through breast milk (hazard ratio, 0.5; 95% confidence interval, 0.3-0.9; P=.03). These results suggest that SLPI plays an important role in reducing HIV-1 transmission through breast milk. | en |
dc.language.iso | en | en |
dc.publisher | University of Nairobi. | en |
dc.title | Salivary secretory leukocyte protease inhibitor is associated with reduced transmission of human immunodeficiency virus type 1 through breast milk | en |
dc.type | Article | en |
local.publisher | Department of Paediatrics and Child Health, Univeristy of Nairobi, Kenya | en |
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