CC and CXC chemokines in breastmilk are associated with mother-to-child HIV-1 transmission.
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Date
2005-10Author
Farquhar, C
Mbori-Ngacha, DA
Redman, MW
Bosire, RK
Lohman, BL
Piantadosi, AL
Goodman, RB
Ruzinski, JT
Emery, SR
Crudder, CH
Overbaugh, JM
John-Stewart, GC
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
INTRODUCTION:
CC and CXC chemokines may play a role in mother-to-child HIV-1 transmission by blocking HIV-1 binding to chemokine receptors and impeding viral entry into cells.
METHODS:
To define correlates of breastmilk chemokines and associations with infant HIV-1 acquisition, chemokines in breastmilk and infant HIV-1 infection risk were assessed in an observational, longitudinal cohort study. We measured MIP-1alpha, MIP-1beta, RANTES, and SDF-1 in month 1 breastmilk specimens from HIV-1-infected women in Nairobi and HIV-1 viral load was calculated in maternal plasma and breastmilk at delivery and 1 month postpartum. Infant infection status was determined at birth and months 1, 3, 6, 9, and 12.
RESULTS:
Among 281 breastfeeding women, 60 (21%) of their infants acquired HIV-1 during follow-up, 39 (65%) of whom became infected intrapartum or after birth. MIP-1alpha, MIP-1beta, RANTES, and SDF-1 were all positively correlated with breastmilk HIV-1 RNA (P<0.0005). Women with clinical mastitis had 50% higher MIP-1alpha and MIP-1beta levels (P<0.001 and P=0.006, respectively) and women with subclinical mastitis (breastmilk Na(+)/K(+)>1) had approximately 70% higher MIP-1alpha, MIP-1beta and RANTES (P<0.002 for all) compared to women without mastitis. Independent of breastmilk HIV-1, increased MIP-1beta and SDF-1 were associated with reduced risk of infant HIV-1 (RR=0.4; 95% CI 0.2-0.9; P=0.03 and RR=0.5; 95% CI=0.3-0.9; P=0.02, respectively) and increased RANTES was associated with higher transmission risk (RR=2.3; 95% CI 1.1- 5.3; P=0.04).
CONCLUSIONS:
These observations suggest a complex interplay between virus levels, breastmilk chemokines, and mother-to-child HIV-1 transmission and may provide insight into developing novel strategies to reduce infection across mucosal surfaces.
URI
http://www.ncbi.nlm.nih.gov/pubmed/16250882http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/30611
Citation
Curr HIV Res. 2005 Oct;3(4):361-9.Publisher
University of Nairobi. Department of Medicine, University of Washington, Seattle Department of Paediatrics and Child Health, Univeristy of Nairobi, Kenya
Collections
- Faculty of Health Sciences (FHS) [10378]