dc.contributor.author | Yenesew Abiy. | |
dc.contributor.author | Kiplagat JT. | |
dc.contributor.author | Derese Solomon. | |
dc.contributor.author | Midiwo Jacob O. | |
dc.contributor.author | Kabaru JM. | |
dc.contributor.author | Heydenreich M. | |
dc.contributor.author | Peter MG. | |
dc.date.accessioned | 2013-06-15T11:52:16Z | |
dc.date.available | 2013-06-15T11:52:16Z | |
dc.date.issued | 2006-05 | |
dc.identifier.citation | Phytochemistry. 2006 May;67(10):988-91. Epub 2006 Feb 17. | en |
dc.identifier.uri | http://www.sciencedirect.com/science/article/pii/S0031942206000045 | |
dc.identifier.uri | http://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34442 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed/16483619 | |
dc.description.abstract | The crude methanol extract of the seeds of Derris trifoliata showed potent and dose dependent larvicidal activity against the 2nd instar larvae of Aedes aegypti. From this extract two unusual rotenoid derivatives, a rotenoloid (named 7a-O-methyl-12a-hydroxydeguelol) and a spirohomooxarotenoid (named spiro-13-homo-13-oxaelliptone), were isolated and characterised. In addition a rare natural chromanone (6,7-dimethoxy-4-chromanone) and the known rotenoids rotenone, tephrosin and dehydrodeguelin were identified. The structures were assigned on the basis of spectroscopic evidence. The larvicidal activity of the crude extract is mainly due to rotenone. | |
dc.description.sponsorship | The crude methanol extract of the seeds of Derris trifoliata showed potent and dose dependent larvicidal activity against the 2nd instar larvae of Aedes aegypti. From this extract two unusual rotenoid derivatives, a rotenoloid (named 7a-O-methyl-12a-hydroxydeguelol) and a spirohomooxarotenoid (named spiro-13-homo-13-oxaelliptone), were isolated and characterised. In addition a rare natural chromanone (6,7-dimethoxy-4-chromanone) and the known rotenoids rotenone, tephrosin and dehydrodeguelin were identified. The structures were assigned on the basis of spectroscopic evidence. The larvicidal activity of the crude extract is mainly due to rotenone | en |
dc.language.iso | en | en |
dc.subject | Derris trifoliata | en |
dc.subject | Leguminosae | en |
dc.subject | Seeds | en |
dc.subject | Rotenoloid | en |
dc.subject | Spirohomooxarotenoid | en |
dc.subject | Rotenoids | en |
dc.subject | 7a-O-methyl-12a-hydroxydeguelol | en |
dc.subject | Spiro-13-homo-13-oxaelliptone | en |
dc.subject | 6,7-Dimethoxy-4-chromanone | en |
dc.subject | Mosquito | en |
dc.subject | Larvicides | en |
dc.subject | Aedes aegypti | en |
dc.title | Two unusual rotenoid derivatives, 7a-O-methyl-12a-hydroxydeguelol and spiro-13-homo-13-oxaelliptone, from the seeds of Derris trifoliata | en |
dc.type | Article | en |
local.publisher | Department of Zoology, University of Nairobi, | en |
local.publisher | Department of Chemistry, University of Nairobi | en |
local.publisher | Institut für Chemie, Universität Potsdam, P.O. Box 601553, D-14415 Potsdam, Germany | en |