Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti
Date
2003-10Author
Yenesew Abiy.
Derese Solomon.
Midiwo Jacob O.
Heydenreich M.
Peter M G.
Type
ArticleLanguage
enMetadata
Show full item recordAbstract
A crude chloroform extract of seeds of Millettia dura Dunn (Leguminosae) showed high activity (LC50 = 3.5 µg ml−1 at 24 h) against second-instar larvae of the mosquito, Aedes aegypti L (Diptera: Culicidae). The rotenoids, deguelin and tephrosin, isolated from the seeds of this plant also showed potent activities, with LC50 values of 1.6 and 1.4 µg ml−1 at 24 h, respectively. The related rotenoids millettone and millettosin were inactive at 20 µg ml−1. Saturation at the B/C ring junction and the presence of methoxy groups at C-2 and/or C-3 in deguelin and tephrosin appear to be important for the observed larvicidal activity. Copyright © 2003 Society of Chemical Industry
URI
http://onlinelibrary.wiley.com/doi/10.1002/ps.740/abstracthttp://erepository.uonbi.ac.ke:8080/xmlui/handle/123456789/34775
http://www.ncbi.nlm.nih.gov/pubmed/14561074
Citation
Yenesew, A., Derese, S., Midiwo, J. O., Heydenreich, M. and Peter, M. G. (2003), Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti. Pest. Manag. Sci., 59: 1159–1161. doi: 10.1002/ps.740Publisher
University of Nairobi Department of Chemistry, University of Nairobi